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Rabbit Polyclonal BBOF1 Antibody

  • 中文名: BBOF1抗体
  • 别    名: CCDC176; C14orf45
货号: IPDX09388
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/200-1/400 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesCCDC176; C14orf45
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human BBOF1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于BBOF1抗体的3篇模拟参考文献示例(注:文献为虚构,仅供参考格式):

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1. **文献名称**: **"BBOF1 Antibody Targets Tumor Microenvironment in Colorectal Cancer"**

**作者**: Yamaguchi T, et al.

**摘要**: 本研究通过免疫组化分析发现,BBOF1抗体能特异性识别肿瘤微环境中过表达的BBOF1蛋白,并揭示其与结肠癌细胞侵袭性的正相关,提示其作为潜在治疗靶点的价值。

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2. **文献名称**: **"Development of a High-Specificity BBOF1 Monoclonal Antibody for Diagnostic Applications"**

**作者**: Saito M, et al.

**摘要**: 文章报道了一种新型单克隆抗体的制备,该抗体能高灵敏度检测血清中的BBOF1抗原,在自身免疫性疾病患者的样本中显示显著升高,可能用于临床诊断标志物开发。

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3. **文献名称**: **"BBOF1 Interaction with TLR4 Signaling Pathway in B Cell Activation"**

**作者**: Suzuki K, et al.

**摘要**: 通过共免疫沉淀和基因敲除实验,本研究证实BBOF1抗体可阻断其与TLR4的相互作用,进而抑制B细胞异常活化,为调控免疫过度反应提供机制依据。

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如需真实文献,建议通过PubMed或Google Scholar以“BBOF1 antibody”为关键词检索,并筛选近年相关研究。

背景信息

The BBOF1 antibody targets the BBOF1 protein, a component of the HAUS complex involved in microtubule nucleation and mitotic spindle assembly. BBOF1 (also known as HAUS6) contributes to chromosomal segregation during cell division by stabilizing γ-tubulin ring complexes, critical for proper microtubule organization. Dysregulation of BBOF1 is linked to mitotic errors, genomic instability, and diseases like cancer. Researchers use BBOF1 antibodies to study its expression, localization, and interactions in cell cycle regulation, often employing techniques such as immunofluorescence, Western blotting, or co-immunoprecipitation. These antibodies help elucidate mechanisms of spindle assembly, mitotic progression, and potential roles in tumorigenesis. Commercial BBOF1 antibodies are typically raised in rabbits or mice, validated for specificity via knockout controls. Their applications span basic cell biology, cancer research, and drug discovery targeting mitotic pathways.

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