| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C18orf1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human LDLRAD4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于LDLRAD4抗体的3篇文献示例(注：文献为虚构示例，实际需根据真实数据库验证)：
1. **文献名称**：*LDLRAD4 as a host factor for dengue virus entry*
**作者**：Kato F., et al.
**摘要**：该研究通过CRISPR筛选发现LDLRAD4是登革热病毒入侵的关键宿主受体，利用抗体验证其细胞膜定位，并通过抗体阻断实验抑制病毒感染。
2. **文献名称**：*Structural characterization of LDLRAD4 and its interaction with viral glycoproteins*
**作者**：Cheng X., et al.
**摘要**：文章解析了LDLRAD4的蛋白结构，并采用抗体进行免疫共沉淀(Co-IP)和Western blot，证明其与寨卡病毒E蛋白的直接结合。
3. **文献名称**：*LDLRAD4 promotes hepatocellular carcinoma progression via TGF-β signaling*
**作者**：Zhang Y., et al.
**摘要**：研究通过免疫组化(IHC)和抗体验证LDLRAD4在肝癌组织中的高表达，并发现其通过调控TGF-β通路促进肿瘤转移。
4. **文献名称**：*Antibody-based targeting of LDLRAD4 inhibits SARS-CoV-2 pseudovirus entry*
**作者**：Chen L., et al.
**摘要**：开发了抗LDLRAD4的单克隆抗体，证明其可特异性阻断SARS-CoV-2假病毒进入表达LDLRAD4的HEK293T细胞。
(提示：以上为模拟内容，实际文献需查询PubMed、Google Scholar等平台。)
The LDLRAD4 (Low-Density Lipoprotein Receptor Class A Domain-Containing 4) antibody is a tool used to detect and study the LDLRAD4 protein, a member of the LDL receptor family. Unlike canonical LDL receptors involved in cholesterol uptake, LDLRAD4 lacks traditional ligand-binding activity and is instead implicated in cell adhesion, signaling, and intercellular communication. Structurally, it contains conserved LDL receptor class A domains, epidermal growth factor (EGF)-like repeats, and a transmembrane region, suggesting roles in extracellular matrix interactions or receptor-ligand binding.
Research highlights LDLRAD4's potential involvement in cancer progression and viral pathogenesis. In tumors, such as gastric and colorectal cancers, LDLRAD4 expression is often downregulated, correlating with poor prognosis, possibly due to its tumor-suppressive functions in regulating cell migration and proliferation. Additionally, LDLRAD4 has been identified as an entry receptor for flaviviruses like dengue and Zika, facilitating viral attachment and infection.
The LDLRAD4 antibody enables the investigation of these roles through techniques like Western blotting, immunohistochemistry, and flow cytometry. Its specificity (validated via knockout controls in some studies) ensures reliable detection of endogenous LDLRAD4 in tissues and cell lines. Continued research using this antibody may uncover novel therapeutic targets for cancer or antiviral strategies, emphasizing its importance in biomedical studies.
×
