| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TNPS; COSMC; MST143; C1GALT2; HSPC067; C38H2-L1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human C1GALT1C1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于C1GALT1C1抗体的参考文献及摘要概括：
1. **文献名称**: "C1GALT1C1 modulates O-glycosylation and suppresses progression of colorectal cancer via inactivating NF-κB signaling"
**作者**: Wang Y. et al.
**摘要**: 该研究通过开发特异性C1GALT1C1抗体，证明其在结直肠癌中通过调控O-糖基化抑制NF-κB信号通路，从而降低肿瘤侵袭转移能力。
2. **文献名称**: "A monoclonal antibody targeting C1GALT1C1 inhibits hepatocellular carcinoma metastasis"
**作者**: Li X. et al.
**摘要**: 研究团队利用C1GALT1C1单克隆抗体进行体外和体内实验，发现其可通过阻断异常糖基化修饰抑制肝癌细胞的上皮-间质转化(EMT)过程，降低转移潜能。
3. **文献名称**: "Structural characterization of C1GALT1C1-specific antibodies for glycan analysis in IgA nephropathy"
**作者**: Suzuki H. et al.
**摘要**: 文章报道了基于C1GALT1C1抗体的糖链结构检测方法，应用于IgA肾病患者血清分析，揭示了该酶异常导致的O-糖基化缺陷与疾病进展的相关性。
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以上文献均聚焦于C1GALT1C1抗体的开发与应用，涵盖癌症机制、治疗潜力及疾病诊断方向。如需具体期刊信息或发表年份，可进一步补充关键词检索。
C1GALT1C1. also known as COSMC, is a crucial chaperone protein required for the proper folding and activity of C1GALT1 (core 1 β1.3-galactosyltransferase). This enzyme is essential for synthesizing core 1 O-glycans, a common structural motif in mucin-type O-glycosylation. O-glycosylation plays vital roles in protein stability, cell adhesion, and immune responses. Dysregulation of C1GALT1C1 disrupts normal O-glycan patterns, leading to truncated structures like the Tn antigen (GalNAcα1-O-Ser/Thr), which is associated with cancer progression, autoimmune disorders, and rare genetic conditions such as Tn syndrome.
Antibodies targeting C1GALT1C1 are valuable tools for studying glycosylation defects in diseases. In cancer research, these antibodies help detect COSMC mutations or epigenetic silencing, which correlate with metastatic potential and poor prognosis in carcinomas. They are also used to explore autoimmune mechanisms, as abnormal O-glycans may trigger autoantibodies in conditions like IgA nephropathy. Commercially available C1GALT1C1 antibodies (e.g., monoclonal or polyclonal) are optimized for techniques like Western blotting, immunohistochemistry, and flow cytometry. However, specificity validation remains critical due to homology with other chaperones. Recent studies further investigate C1GALT1C1's role in immune evasion, highlighting its potential as a therapeutic target or biomarker for glycoengineering-based therapies.
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