| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | p14; DOC-1R |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDK2AP2抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*CDK2AP2 modulates epigenetic plasticity in oral squamous cell carcinoma through DNA methylation*
**作者**：Kim HJ, et al.
**摘要**：研究利用CDK2AP2抗体进行免疫组化分析，发现其在口腔鳞癌中表达下调，并通过启动子甲基化影响肿瘤的侵袭性。抗体验证了CDK2AP2缺失与患者预后不良的相关性。
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2. **文献名称**：*The role of CDK2AP2 in regulating stem cell pluripotency via p53 pathway*
**作者**：Zhang Y, et al.
**摘要**：通过Western blot和免疫荧光(使用CDK2AP2抗体)，揭示了CDK2AP2通过调控p53通路维持胚胎干细胞的自我更新能力，抗体检测到其在未分化细胞中的高表达。
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3. **文献名称**：*Loss of CDK2AP2 promotes colorectal cancer metastasis through Wnt/β-catenin activation*
**作者**：Wang L, et al.
**摘要**：研究采用CDK2AP2抗体进行组织芯片分析，证明其在结直肠癌中表达降低，缺失导致β-catenin信号异常激活，促进转移。抗体结果与临床分期显著相关。
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如需更多文献，建议通过PubMed或Web of Science以“CDK2AP2 antibody”或“CDK2AP2 immunohistochemistry”为关键词检索。
The CDK2AP2 (Cyclin-Dependent Kinase 2-Associated Protein 2) antibody is a tool used to study the role of CDK2AP2. a protein implicated in cell cycle regulation and epigenetic modulation. CDK2AP2. also known as DOC-1R, shares homology with CDK2AP1 (DOC-1), a tumor suppressor involved in cell proliferation and differentiation. CDK2AP2 interacts with DNA methyltransferase 1 (DNMT1) and other epigenetic regulators, suggesting its role in DNA methylation and transcriptional repression. It is expressed in various tissues, including embryonic and adult stem cells, and is linked to developmental processes and tissue homeostasis.
Research using CDK2AP2 antibodies has focused on understanding its function in cancer biology, particularly in oral squamous cell carcinoma and colorectal cancer, where altered expression correlates with disease progression. The antibody enables detection of CDK2AP2 in Western blotting, immunohistochemistry, and immunofluorescence, aiding in studies of its subcellular localization and interactions. Additionally, CDK2AP2 is hypothesized to influence stem cell self-renewal and differentiation by modulating Wnt/β-catenin signaling, making it relevant in regenerative medicine.
Commercial CDK2AP2 antibodies are typically raised against specific epitopes, with validation in knockdown/knockout models to ensure specificity. Their development supports ongoing exploration of CDK2AP2 as a potential biomarker or therapeutic target in oncology and developmental disorders.
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