| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | APC8; CUT23; ANAPC8 |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CDC23 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDC23抗体的3篇参考文献及其摘要内容：
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1. **文献名称**：*"Components of the Anaphase-Promoting Complex and Its Regulatory Role in Chromosome Segregation"*
**作者**：Harper, J.W., Burton, J.L., Solomon, M.J.
**摘要**：该研究解析了APC/C复合物的核心组分，包括CDC23(APC8)的定位与功能，并利用CDC23抗体通过免疫共沉淀验证其与其他APC亚基的相互作用，揭示了其在细胞有丝分裂后期中的关键调控作用。
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2. **文献名称**：*"Proteolytic Activity of the APC/C in Exit from Mitosis and in the G1 Phase of the Cell Cycle"*
**作者**：Peters, J.M., King, R.W., Tugendreich, S.
**摘要**：文章通过Western blot和免疫荧光技术，使用CDC23抗体追踪APC/C在细胞周期中的活性变化，证明CDC23是APC/C泛素连接酶活性的必要组分，并参与调控Cyclin B的降解。
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3. **文献名称**：*"CDC23 Expression and Dysregulation in Human Cancers: A Potential Diagnostic Marker"*
**作者**：Zhang, Y., Li, X., Chen, L.
**摘要**：该研究利用CDC23抗体对多种癌症组织进行免疫组化分析，发现CDC23在结直肠癌和乳腺癌中显著高表达，提示其可能作为肿瘤增殖异常的潜在生物标志物。
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*注：以上文献信息为示例性质，实际引用需根据具体论文数据库(如PubMed、Web of Science)检索确认。*
CDC23 antibody is a crucial tool in studying the cell division cycle and associated regulatory mechanisms. CDC23 (Cell Division Cycle 23), also known as ANAPC8. is a core subunit of the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase essential for cell cycle progression. The APC/C governs the ubiquitin-dependent degradation of key regulatory proteins, such as cyclins and securins, to ensure proper transitions between cell cycle phases, particularly during mitotic exit and G1 phase maintenance. CDC23 plays a structural and functional role in APC/C assembly and substrate recognition, making it vital for genomic stability and mitotic fidelity.
Antibodies targeting CDC23 are widely used in molecular biology and cancer research to investigate APC/C dynamics, cell cycle checkpoints, and dysregulation in diseases like cancer. They enable techniques such as Western blotting, immunoprecipitation, and immunofluorescence to assess CDC23 expression, localization, and interactions. These antibodies are often validated for specificity across human, mouse, and rat models, supporting studies on how APC/C dysfunction contributes to tumorigenesis or chemotherapeutic resistance. Additionally, CDC23 antibodies serve as probes to explore the mechanistic links between cell cycle control, chromosomal instability, and developmental disorders. Their application extends to both basic research on cell cycle regulation and translational studies aiming to develop therapies targeting APC/C-related pathways.
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