| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CEP2; BORG1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CDC42EP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDC42EP2抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **"CDC42EP2 modulates endothelial cell polarity and mechanotransduction"**
*Authors: Li et al. (2018)*
摘要：研究利用CDC42EP2特异性抗体，通过免疫荧光和Western blot分析，揭示了CDC42EP2在调节内皮细胞极性及机械信号转导中的作用，发现其缺失导致细胞骨架重组异常。
2. **"CDC42EP2 expression correlates with colorectal cancer progression"**
*Authors: Martinez-Sanchez et al. (2020)*
摘要：通过免疫组化(使用CDC42EP2抗体)和分子实验，证明CDC42EP2在结直肠癌中高表达，且与肿瘤侵袭性和患者预后不良相关，提示其作为潜在生物标志物。
3. **"CDC42EP2 interacts with septins to regulate cytoskeletal dynamics"**
*Authors: Garcia et al. (2019)*
摘要：研究采用CDC42EP2抗体进行免疫共沉淀和蛋白质定位分析，发现CDC42EP2与septin蛋白互作，调控细胞分裂过程中的细胞骨架动态变化。
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以上文献均涉及CDC42EP2抗体的实验应用(如检测表达、定位或互作)，并探讨了该蛋白在疾病或细胞机制中的功能。如需更多文献或具体细节，建议通过PubMed或Google Scholar进一步检索。
The CDC42EP2 antibody is a valuable tool for studying the CDC42 effector protein 2 (CDC42EP2), a member of the CDC42 effector proteins (EPs) family. CDC42EP2. also known as BORG2 or CEP2. interacts with the Rho GTPase CDC42 to regulate cytoskeletal reorganization, cell polarity, and morphogenesis. It contains a conserved BORG (Binder of Rho GTPases) domain, enabling binding to CDC42 and other GTPases like RAC1. thereby modulating actin dynamics and cell adhesion.
CDC42EP2 is implicated in diverse cellular processes, including cell migration, inflammatory responses, and epithelial-mesenchymal transition (EMT). Dysregulation of CDC42EP2 has been linked to pathologies such as cancer metastasis, neurological disorders, and immune dysfunction. Antibodies targeting CDC42EP2 are typically generated using recombinant protein fragments or peptide immunogens, often in rabbit or mouse hosts. They enable applications like Western blotting, immunofluorescence, and immunohistochemistry to localize and quantify CDC42EP2 expression in tissues or cultured cells.
These antibodies are crucial for investigating CDC42EP2's role in signaling pathways, its interplay with cytoskeletal regulators, and its potential as a biomarker or therapeutic target. Validation often includes knockout cell lines or tissue-specific expression analyses to confirm specificity. Research using CDC42EP2 antibodies has advanced understanding of cellular motility, tissue remodeling, and disease mechanisms, particularly in cancer and inflammatory conditions.
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