| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DOC1; ST19; DORC1; doc-1; p12DOC-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于CDK2AP1抗体的参考文献概览，涵盖其在不同疾病模型中的应用：
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1. **文献名称**: *CDK2AP1 modulates apoptosis and proliferation in endoreduplicated oral carcinoma cells*
**作者**: Kim SS et al.
**摘要**: 本研究利用CDK2AP1特异性抗体，通过免疫组化和Western blot技术，发现CDK2AP1在口腔鳞状细胞癌中表达下调，其缺失导致细胞周期异常和凋亡减少，提示其作为肿瘤抑制因子的作用。
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2. **文献名称**: *Cdk2ap1 interacts with E-cadherin and regulates intestinal epithelial differentiation*
**作者**: Suzuki A et al.
**摘要**: 通过免疫共沉淀结合CDK2AP1抗体，揭示了CDK2AP1通过稳定E-cadherin复合物调控肠道上皮细胞分化，其表达缺失与结直肠癌侵袭性相关，为靶向治疗提供依据。
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3. **文献名称**: *Loss of CDK2AP1 promotes stem-like phenotypes in prostate cancer*
**作者**: Chen Z et al.
**摘要**: 使用CDK2AP1抗体进行组织芯片分析，发现前列腺癌中CDK2AP1低表达与癌症干细胞标志物(如OCT4)上调相关，实验表明其通过p53通路抑制肿瘤干细胞特性。
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**备注**：以上信息为模拟摘要，实际文献需通过PubMed或Web of Science以关键词“CDK2AP1 antibody”或“CDK2AP1 immunohistochemistry”检索获取。部分经典研究可能发表于2000年代初期，建议补充最新文献以覆盖技术进展。
The CDK2AP1 (Cyclin-Dependent Kinase 2-Associated Protein 1) antibody is a tool used to detect and study the CDK2AP1 protein, a key regulator of cell cycle progression and epigenetic modulation. CDK2AP1. also known as DOC-1. interacts with cyclin-dependent kinase 2 (CDK2) to inhibit its activity, influencing G1/S phase transition and promoting cell cycle arrest or apoptosis. It plays roles in DNA replication initiation by binding to DNA polymerase α/primase, and is implicated in stem cell differentiation, embryonic development, and epigenetic regulation through histone modification.
Research highlights CDK2AP1's tumor-suppressive functions, as its downregulation is observed in cancers like oral squamous cell carcinoma and colorectal cancer, correlating with poor prognosis. The antibody enables detection of CDK2AP1 expression levels in tissues or cells via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It is critical for exploring CDK2AP1's molecular mechanisms in disease contexts, including carcinogenesis, metabolic disorders, and developmental defects. Commercial CDK2AP1 antibodies are typically validated for specificity and sensitivity, supporting both basic research and translational studies aiming to develop diagnostic biomarkers or therapeutic strategies targeting CDK2AP1-related pathways.
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