| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PCCP1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CDYL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于模拟生成的3篇与CDYL2抗体相关的参考文献示例(请注意，这些文献信息为假设性内容，实际引用时请核实真实数据库)：
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1. **文献名称**: "CDYL2 Antibody Generation and Application in Germ Cell Development Studies"
**作者**: Zhang Y, et al. (2020)
**摘要**: 本研究开发了一种高特异性CDYL2多克隆抗体，并通过Western blot和免疫荧光验证其在哺乳动物睾丸组织中的表达。结果表明，CDYL2在精子发生晚期的圆形精子细胞中高表达，提示其可能在染色质重塑中发挥作用。
2. **文献名称**: "CDYL2 as an Epigenetic Regulator in Breast Cancer: Insights from Antibody-Based Profiling"
**作者**: Patel R, et al. (2018)
**摘要**: 利用商业化CDYL2单克隆抗体对乳腺癌组织芯片进行免疫组化分析，发现CDYL2在雌激素受体阴性(ER-)肿瘤中显著高表达，并与患者预后不良相关。机制研究表明CDYL2可能通过招募组蛋白去乙酰化酶(HDACs)促进基因沉默。
3. **文献名称**: "Characterization of CDYL2 Antibody for Chromatin Immunoprecipitation in Neural Stem Cells"
**作者**: Kim S, et al. (2021)
**摘要**: 本文验证了一种适用于ChIP-seq的CDYL2兔源抗体，证实其在小鼠神经干细胞中与异染色质区域(如LINE-1重复序列)特异性结合，支持CDYL2在维持基因组稳定性中的潜在功能。
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**注意事项**：
- 上述文献为模拟生成，实际研究中请通过PubMed、Google Scholar等平台以关键词“CDYL2 antibody”、“CDYL2 immunohistochemistry”等检索真实文献。
- 若研究较少，可扩展至CDYL家族(如CDYL1)或表观遗传调控相关抗体的文献作为参考。
The CDYL2 (Chromodomain Y-like 2) antibody is a tool used to detect the CDYL2 protein, a member of the chromodomain-containing protein family involved in epigenetic regulation. CDYL2 shares structural homology with CDYL1. including a chromodomain that binds methylated histones (e.g., H3K9me2/3) and a catalytic domain with enoyl-CoA hydratase activity. Functionally, CDYL2 acts as a transcriptional corepressor by recruiting histone-modifying enzymes, such as histone deacetylases (HDACs) and histone methyltransferases, to mediate chromatin condensation and gene silencing. It plays roles in spermatogenesis, neuronal development, and cellular differentiation. Dysregulation of CDYL2 has been linked to cancers, including germ cell tumors and prostate cancer, where it may influence oncogenic pathways or tumor suppression.
The CDYL2 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study protein expression, localization, and interactions in tissues or cell lines. Researchers employ it to explore CDYL2's involvement in epigenetic mechanisms, germ cell biology, and disease pathogenesis. Antibody validation typically includes testing in CDYL2-knockout models to confirm specificity. Commercial CDYL2 antibodies are often generated using immunogens derived from conserved regions of the human protein. However, cross-reactivity with CDYL1 or other family members must be ruled out during experimental design. Its applications extend to developmental biology, cancer research, and studies of chromatin dynamics.
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