| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CDO; CDON1; HPE11; ORCAM |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CDON |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与CDON抗体相关的参考文献示例(内容基于虚构研究概括，仅供参考)：
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1. **文献名称**: *CDON Expression in Hepatocellular Carcinoma: Prognostic Implications and Antibody Development*
**作者**: Kang JS et al.
**摘要**: 本研究开发了一种高特异性CDON单克隆抗体，通过免疫组化和Western blot技术分析肝癌组织，发现CDON蛋白表达显著下调，且低表达与患者生存率降低相关，提示CDON可能作为肝癌的潜在抑癌标志物。
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2. **文献名称**: *Immunolocalization of CDON in Neural Development Using a Novel Polyclonal Antibody*
**作者**: Zhang Y et al.
**摘要**: 研究团队制备了兔源多克隆CDON抗体，用于小鼠胚胎神经管发育研究。免疫荧光结果显示CDON在神经嵴细胞中高表达，并证实其通过调控Shh信号通路参与神经管闭合过程，为神经发育疾病机制提供新见解。
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3. **文献名称**: *CDON Antibody Validation for Muscle Regeneration Studies*
**作者**: Smith R et al.
**摘要**: 本研究系统验证了商品化CDON抗体的特异性(通过敲除细胞系验证)，并应用于骨骼肌再生模型。结果显示CDON在肌卫星细胞中动态表达，提示其可能在肌肉损伤修复中起关键作用。
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注：以上文献为示例性内容，实际研究中请通过PubMed或Web of Science检索真实发表的论文。
CDON (Cell Adhesion Molecule-Related/Down-Regulated by Oncogenes) is a transmembrane protein belonging to the immunoglobulin superfamily, primarily involved in cell-cell adhesion and signaling processes. It plays a critical role during embryonic development, particularly in tissue patterning, neurite outgrowth, and myogenesis. CDON acts as a receptor or co-receptor in the Hedgehog (Hh) signaling pathway, interacting with ligands like Sonic Hedgehog (Shh) to regulate cell differentiation and proliferation. Studies have linked CDON mutations to congenital disorders such as holoprosencephaly, highlighting its importance in craniofacial and neural development.
In cancer, CDON exhibits context-dependent roles. While initially identified as a tumor suppressor due to its downregulation in certain malignancies, recent evidence suggests it may also promote tumor progression in specific contexts. CDON antibodies are essential tools for investigating these dual roles, enabling researchers to detect protein expression, localization, and interaction partners via techniques like immunohistochemistry, Western blotting, or co-immunoprecipitation. Such studies contribute to understanding CDON's involvement in developmental defects, cancer biology, and potential therapeutic targeting. However, its functional complexity warrants further research to clarify context-specific mechanisms and therapeutic applicability.
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