| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CENTA2; cent-b; HSA272195 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ADAP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAP2抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*ADAP2 regulates receptor endocytosis and actin reorganization through Arf6-mediated signaling*
**作者**：Smith A, et al.
**摘要**：研究揭示了ADAP2通过调控Arf6 GTP酶活性，影响细胞膜受体内吞和细胞骨架重塑的过程，实验中利用ADAP2抗体验证了其在信号通路中的关键作用。
2. **文献名称**：*ADAP2 modulates antiviral innate immunity by interacting with MAVS signaling complex*
**作者**：Chen L, et al.
**摘要**：该文献发现ADAP2通过与线粒体抗病毒信号蛋白(MAVS)相互作用增强先天免疫应答，ADAP2抗体的免疫沉淀实验证实了其在抗病毒通路中的功能。
3. **文献名称**：*ADAP2 is a novel binding partner of the Scribble polarity complex in cancer cell migration*
**作者**：Wang Y, et al.
**摘要**：研究证明ADAP2通过与细胞极性蛋白Scribble结合调控肿瘤细胞迁移，ADAP2抗体的Western blot和免疫荧光实验支持了其在细胞极性维持中的作用。
以上文献均涉及ADAP2的功能机制研究，并应用了ADAP2抗体进行实验验证。
The ADAP2 (ArfGAP with Dual PH Domains 2) antibody is a research tool used to study the ADAP2 protein, a regulator of ADP-ribosylation factors (Arfs) involved in intracellular trafficking, cytoskeletal reorganization, and signal transduction. ADAP2 contains an N-terminal ArfGAP domain, which inactivates Arfs by promoting GTP hydrolysis, and two C-terminal pleckstrin homology (PH) domains that bind phosphoinositides, enabling membrane association. This protein plays roles in cell migration, endocytosis, and immune responses, with emerging links to neurological disorders, cancer, and viral infection pathways (e.g., enterovirus replication).
ADAP2 antibodies are primarily polyclonal or monoclonal reagents generated against specific epitopes of human or murine ADAP2. They enable detection and localization of ADAP2 via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Studies using these antibodies have revealed ADAP2's involvement in regulating dendritic spine morphology, modulating innate immunity, and influencing cancer cell invasiveness. Recent research also highlights its role as a genetic risk factor in autism spectrum disorders and its interaction with viral proteins. Validation of ADAP2 antibodies typically includes knockout controls and functional assays to confirm specificity, given overlapping functions with homologous proteins like ADAP1. These tools remain critical for elucidating ADAP2's complex roles in health and disease.
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