| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CERD4; BAF45C |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human DPF3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DPF3抗体的3篇参考文献的简要概括(注：文献为模拟示例，实际文献需根据数据库检索验证)：
1. **文献名称**：*DPF3 regulates chromatin remodeling and cardiac development through BAF complex interaction*
**作者**：Zhang, Y. et al.
**摘要**：本研究通过构建DPF3基因敲除小鼠模型，结合特异性DPF3抗体进行染色质免疫沉淀(ChIP)和免疫荧光染色，揭示了DPF3通过BAF复合物调控心脏发育相关基因的染色质重塑机制。
2. **文献名称**：*Characterization of a monoclonal antibody against DPF3 for cancer biomarker discovery*
**作者**：Lee, S. & Kim, H.
**摘要**：报道了一种新型抗DPF3单克隆抗体的开发与验证，该抗体在Western blot和免疫组化中表现出高特异性，并用于检测多种肿瘤组织中DPF3的异常表达，提示其作为癌症生物标志物的潜力。
3. **文献名称**：*DPF3 mediates neurodevelopmental disorders via epigenetic modulation*
**作者**：Garcia, R. et al.
**摘要**：利用DPF3抗体进行免疫共沉淀和蛋白质质谱分析，发现DPF3与神经元分化相关的染色质调控蛋白相互作用，其表达缺失导致神经发育异常，为相关疾病的分子机制提供了新见解。
4. **文献名称**：*Antibody-based profiling of DPF3 isoforms in human tissues*
**作者**：Wang, Q. et al.
**摘要**：通过针对不同DPF3异构体的多克隆抗体，系统分析了其在心脏、脑和肾脏组织中的分布差异，揭示了异构体特异性功能及其在疾病中的潜在作用。
建议通过PubMed或Google Scholar检索关键词“DPF3 antibody”、“DPF3 BAF complex”或“DPF3 immunohistochemistry”获取真实文献。
The DPF3 (d4-family zinc finger protein 3) antibody is a tool used to study the DPF3 protein, a member of the d4-family of chromatin-associated proteins. DPF3. also known as BAF45c or SMARCG2. functions as a subunit of the Brg1/Brahma-associated factors (BAF) chromatin remodeling complex, which regulates gene expression by altering chromatin structure. It contains two plant homeodomain (PHD) zinc fingers that mediate interactions with histones, particularly acetylated H3 and H4. linking chromatin modification to transcriptional regulation.
DPF3 plays critical roles in cardiac and skeletal muscle development, with studies implicating it in heart morphogenesis and myogenesis. Aberrant DPF3 expression or mutations are associated with developmental disorders and cancers, including medulloblastoma and ovarian cancer. The DPF3 antibody is widely used in research to investigate its involvement in chromatin dynamics, tissue-specific differentiation pathways, and disease mechanisms. It enables detection of DPF3 in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Recent studies also explore its potential as a therapeutic target, emphasizing its dual role as an oncogene or tumor suppressor depending on cellular context. The antibody's specificity and reliability make it essential for dissecting DPF3's functional interplay within the BAF complex and its broader epigenetic regulatory network.
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