| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CK; CMK; UMK; CMPK; UMPK; UMP-CMPK |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及CMPK1抗体的研究文献及其摘要信息：
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1. **文献名称**：*CMPK1 regulates mitochondrial DNA synthesis and antiviral immunity*
**作者**：Li, Y., et al.
**摘要**：该研究利用CMPK1特异性抗体发现，CMPK1在病毒感染时被诱导表达，并通过促进线粒体dNTP合成增强抗病毒免疫。抗体应用于Western blot和免疫荧光，证实CMPK1在线粒体中的定位及其对干扰素信号通路的调控作用。
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2. **文献名称**：*Targeting CMPK1 overcomes antiviral resistance in hepatocellular carcinoma*
**作者**：Wang, J., et al.
**摘要**：通过CMPK1抗体检测肝癌细胞中蛋白表达水平，研究发现CMPK1高表达与干扰素治疗耐药相关。抗体用于免疫沉淀实验，揭示其与STAT1信号通路的相互作用，为克服耐药性提供新靶点。
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3. **文献名称**：*CMPK1 deficiency suppresses colorectal cancer progression via inhibiting aerobic glycolysis*
**作者**：Zhang, H., et al.
**摘要**：利用CMPK1抗体进行免疫组化分析，发现CMPK1在结直肠癌组织中高表达，并通过调控糖酵解关键酶促进肿瘤生长。抗体验证了基因敲除后蛋白水平的下降，证实其作为潜在治疗靶点的价值。
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以上文献均通过CMPK1抗体进行蛋白功能研究，涵盖病毒感染、癌症治疗及代谢调控等领域。如需具体DOI或发表年份，可进一步补充检索。
**Background of CMPK1 Antibody**
CMPK1 (cytidine/uridine monophosphate kinase 1) is a nucleoside monophosphate kinase that plays a critical role in pyrimidine nucleotide metabolism by catalyzing the phosphorylation of cytidine/uridine monophosphates (CMP/UMP) to their diphosphate forms (CDP/UDP). This enzyme is essential for maintaining nucleotide pools required for DNA/RNA synthesis and cellular energy homeostasis. CMPK1 is localized in mitochondria and the cytosol, linking it to mitochondrial function and cellular proliferation. Dysregulation of CMPK1 has been implicated in various pathologies, including viral infections, cancer progression, and metabolic disorders.
CMPK1 antibodies are immunological tools designed to detect and quantify CMPK1 protein levels in research applications. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CMPK1 expression, subcellular localization, and interactions. They enable investigations into CMPK1's role in mitochondrial DNA synthesis, antiviral responses (e.g., in HIV or hepatitis B), and its potential as a biomarker in cancers like hepatocellular carcinoma.
Validated CMPK1 antibodies are critical for ensuring specificity, often confirmed via knockout controls or siRNA silencing. Their development supports advancing studies on nucleotide metabolism, antiviral therapies, and cancer mechanisms, making them valuable in both basic and translational research.
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