| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/400 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CLCNL2; CLIC2b; MRXS32; XAP121 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Fusion protein of human CLIC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CLIC2抗体的3篇参考文献(基于公开文献信息概括整理)：
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1. **文献名称**：*CLIC2抗体在X-linked智力障碍相关研究中的应用*
**作者**：Smith A, et al.
**摘要概括**：本研究利用特异性CLIC2抗体，通过免疫印迹和免疫荧光技术，发现CLIC2蛋白在神经细胞中的异常表达与X-linked智力障碍相关，揭示了其通过调节离子通道功能影响神经元发育的机制。
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2. **文献名称**：*CLIC2抗体揭示其在乳腺癌细胞迁移中的作用*
**作者**：Chen L, et al.
**摘要概括**：文章通过CLIC2抗体的免疫组化分析，发现CLIC2在乳腺癌组织中高表达，并证明其通过调控细胞内氯离子浓度促进肿瘤细胞侵袭，为靶向CLIC2的癌症治疗提供了实验依据。
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3. **文献名称**：*斑马鱼模型中CLIC2抗体的功能验证及发育研究*
**作者**：Wang Y, et al.
**摘要概括**：研究通过CLIC2抗体的免疫沉淀和基因敲降实验，证实CLIC2在斑马鱼心脏发育中起关键作用，其缺失导致心脏形态异常，提示CLIC2可能参与胚胎发育的离子稳态调控。
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**备注**：上述文献为示例性内容，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。若需具体文章，建议结合关键词“CLIC2 antibody”或“CLIC2 immunohistochemistry”进一步筛选。
The chloride intracellular channel 2 (CLIC2) protein belongs to the CLIC family, a group of redox-regulated proteins that transition between soluble and membrane-bound forms. CLIC2 is implicated in regulating intracellular chloride ion transport, cellular homeostasis, and membrane potential. Structurally, it shares a conserved glutathione S-transferase (GST)-like domain, enabling redox-sensitive ion channel activity. While its exact physiological role remains under investigation, CLIC2 is expressed in various tissues, including the heart, skeletal muscle, and reproductive organs, and is linked to cellular processes like apoptosis, cell cycle regulation, and organelle acidification.
CLIC2 antibodies are critical tools for studying its expression, localization, and function in health and disease. Research highlights its potential involvement in pathologies, such as cancer and X-linked intellectual disability (XLID). In cancer, CLIC2 overexpression is observed in certain tumors, correlating with metastasis and poor prognosis. Mutations in CLIC2 have also been associated with XLID disorders, possibly due to disrupted ion homeostasis affecting neuronal development. Antibodies targeting CLIC2 enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding in mechanistic studies and biomarker discovery. Their development continues to support exploration of CLIC2 as a therapeutic target or diagnostic tool.
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