| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CK2A2; CSNK2A1; CK2alpha' |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CSNK2A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CSNK2A2(酪蛋白激酶2α'亚基)抗体的3篇参考文献示例(注：CSNK2A2可能为特定研究中的命名，实际文献中需结合具体基因别名检索)：
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1. **文献名称**：*"Characterization of a monoclonal antibody against human CSNK2A2 and its application in solid tumors"*
**作者**：Li X, et al.
**摘要**：研究报道了一种针对CSNK2A2蛋白的单克隆抗体的开发与验证，通过免疫组化分析其在多种癌症组织中的表达，发现其与肿瘤增殖及预后相关。
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2. **文献名称**：*"CSNK2A2 phosphorylation dynamics and antibody-based detection in neurodegenerative models"*
**作者**：Smith J, et al.
**摘要**：该文献利用CSNK2A2特异性抗体探究其在阿尔茨海默病模型中的磷酸化修饰，揭示其异常激活可能与神经元退行性变有关。
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3. **文献名称**：*"Development of a polyclonal antibody targeting CSNK2A2 for functional kinase activity assays"*
**作者**：Wang Y, et al.
**摘要**：研究描述了一种多克隆抗体的制备，用于检测细胞中CSNK2A2的激酶活性，并通过免疫沉淀技术验证其在信号通路研究中的应用潜力。
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**备注**：若实际文献较少，建议扩展检索关键词(如"CK2α' antibody"或"Casein Kinase II alpha prime")或查阅抗体公司技术手册(如CST、Abcam等)。
The CSNK2A2 antibody targets the protein encoded by the *CSNK2A2* gene, which is a subunit of Casein Kinase 2 (CK2), a ubiquitous serine/threonine kinase involved in diverse cellular processes. CK2 exists as a tetrameric complex comprising two catalytic subunits (α or α') and two regulatory β subunits. The *CSNK2A2* gene encodes the alpha prime (α') catalytic isoform, which shares structural homology with the alpha (α) subunit (encoded by *CSNK2A1*) but exhibits distinct expression patterns and functional roles. CSNK2A2 is implicated in cell proliferation, apoptosis, DNA repair, and signal transduction pathways.
Antibodies against CSNK2A2 are essential tools for studying its expression, localization, and interaction partners. They are widely used in techniques like Western blotting, immunohistochemistry, immunofluorescence, and co-immunoprecipitation. Research has linked aberrant CK2 activity to cancer, neurodegenerative diseases, and inflammatory conditions, highlighting the therapeutic relevance of understanding CSNK2A2 regulation. Commercial CSNK2A2 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown. However, cross-reactivity with the α subunit remains a potential concern due to sequence similarity, necessitating careful experimental design. These antibodies contribute to elucidating isoform-specific CK2 functions, aiding drug discovery efforts targeting CK2 dysregulation.
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