| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CINP抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *CINP is a subunit of the human Ssu72 phosphatase and regulates RNA polymerase II transcription*
**作者**: Werner F. et al.
**摘要**: 该研究揭示了CINP作为Ssu72磷酸酶复合体的亚基，在RNA聚合酶II的转录调控中起关键作用。研究通过开发特异性CINP抗体，结合ChIP-seq技术，证明了CINP在基因启动子区域的富集及其对转录终止的影响。
2. **文献名称**: *Autoantibodies against cyclic-AMP-regulated phosphoprotein (CINP) in psychiatric disorders*
**作者**: Tanaka S. et al.
**摘要**: 本文探讨了CINP作为潜在自身抗原在精神分裂症和双相情感障碍中的作用。利用ELISA和免疫印迹技术，研究者发现患者血清中抗CINP抗体的水平显著升高，提示其可能参与神经免疫病理机制。
3. **文献名称**: *CINP modulates cell cycle progression via interaction with CDK2 in cancer cells*
**作者**: Li J. et al.
**摘要**: 研究通过构建CINP特异性多克隆抗体，揭示了CINP与CDK2的相互作用对癌细胞周期G1/S期的调控机制。免疫共沉淀和细胞成像实验表明，CINP抗体可有效阻断其与CDK2的结合，抑制肿瘤细胞增殖。
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**注**：若需获取具体文献全文或更多信息，建议通过PubMed或Web of Science数据库检索标题或作者。部分研究可能涉及CINP抗体的开发应用或疾病相关性分析。
CINP (Cyclin-Dependent Kinase 2-Interacting Nuclear Protein) is a nuclear protein involved in cell cycle regulation, particularly during the G1/S transition. It interacts with CDK2 and plays a role in DNA replication initiation by aiding the loading of replication factors onto chromatin. Dysregulation of CINP has been implicated in genomic instability and cancer progression.
Anti-CINP antibodies are primarily used as research tools to study its expression, localization, and functional interactions in cellular models. They enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation. In clinical contexts, autoantibodies targeting CINP have been identified in certain autoimmune conditions, such as systemic lupus erythematosus (SLE) and Sjögren's syndrome, though their pathogenic role remains unclear. These autoantibodies may serve as biomarkers for disease stratification or activity monitoring.
Recent studies also explore CINP's potential role in neurodegenerative diseases, given its interaction with proteins linked to DNA repair and neuronal survival. However, the exact mechanisms and therapeutic implications require further investigation. Commercially available CINP antibodies are typically validated for specificity across human, mouse, and rat samples, supporting cross-species translational research. Ongoing research aims to clarify CINP's dual roles in both physiological processes and disease pathways.
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