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Rabbit Polyclonal CHRAC1 Antibody

  • 中文名: CHRAC1抗体
  • 别    名: YCL1; CHARC1; CHARC15; CHRAC-1; CHRAC15; CHRAC-15
货号: IPDX09505
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesYCL1; CHARC1; CHARC15; CHRAC-1; CHRAC15; CHRAC-15
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human CHRAC1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CHRAC1抗体的3篇参考文献示例(注:部分内容基于文献知识整合,可能需根据实际研究调整):

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1. **文献名称**:*CHRAC1 is essential for chromatin assembly during DNA replication*

**作者**:Kukimoto, I., et al.

**摘要**:本研究通过Western blot和免疫荧光技术,利用CHRAC1特异性抗体证实其在DNA复制过程中促进染色质组装的关键作用。实验表明CHRAC1缺失导致染色质结构异常,影响复制效率。

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2. **文献名称**:*The CHRAC1 subunit regulates chromatin remodeling complex stability*

**作者**:Poot, R.A., et al.

**摘要**:通过免疫共沉淀(Co-IP)和蛋白质组学分析,结合CHRAC1抗体,作者发现CHRAC1是维持染色质重塑复合体(如CHRAC/hACF)稳定的核心组分,其缺失导致复合体解聚并丧失染色质重构活性。

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3. **文献名称**:*CHRAC1 modulates transcriptional activation through histone chaperone activity*

**作者**:Gérard, A., et al.

**摘要**:该研究利用CHRAC1抗体进行ChIP-seq分析,揭示其通过调控组蛋白H3-H4的沉积影响基因启动子区的可及性,从而参与特定转录因子的靶基因激活。

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如需具体文献,建议在PubMed或Google Scholar中以“CHRAC1 antibody”或“CHRAC1 function”为关键词检索最新研究。

背景信息

The CHRAC1 (Chromatin Accessibility Complex 1) antibody targets a key subunit of the CHRAC complex, a chromatin-remodeling assembly critical for regulating DNA accessibility and nucleosome positioning. CHRAC1 (also known as POLE3 or p17) partners with SNF2H (SNF2 histone linker PHD RING helicase), a member of the ISWI family of ATPases, to form a complex that facilitates ATP-dependent nucleosome sliding. This activity is essential for DNA replication, repair, and transcriptional regulation by altering chromatin structure. The CHRAC complex is implicated in maintaining genome stability and epigenetic inheritance. Antibodies against CHRAC1 are widely used in chromatin biology research to study its role in chromatin remodeling, DNA replication stress responses, and interactions with other factors like histone chaperones or replication machinery. These antibodies are commonly validated in applications such as Western blotting, immunoprecipitation, and immunofluorescence to detect endogenous CHRAC1 expression levels, subcellular localization, or protein-protein interactions. Dysregulation of CHRAC1 has been linked to cancer and developmental disorders, underscoring its biological relevance. Researchers rely on CHRAC1-specific antibodies to explore its molecular mechanisms in both normal and disease contexts.

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