| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CIRP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CIRBP抗体的3篇参考文献示例(注：文献标题和作者为虚构示例，仅供格式参考)：
1. **标题**：*CIRBP mediates cold adaptation in neuronal cells via RNA stabilization*
**作者**：Smith A, et al.
**摘要**：研究低温环境下CIRBP对神经元RNA稳定性的调控作用，通过Western blot和免疫荧光技术(使用CIRBP特异性抗体)证实其蛋白表达上调，并揭示其抗凋亡机制。
2. **标题**：*CIRBP antibody-based detection in sepsis-induced organ damage*
**作者**：Lee B, et al.
**摘要**：探讨脓毒症模型中CIRBP的病理作用，利用CIRBP单克隆抗体进行免疫组化分析，发现其在肝、肾组织中显著富集，提示其参与炎症反应调控。
3. **标题**：*CIRBP promotes tumor metastasis through post-transcriptional regulation*
**作者**：Chen C, et al.
**摘要**：通过免疫沉淀(IP)结合CIRBP抗体鉴定其结合mRNA靶点，揭示CIRBP在乳腺癌转移中的分子机制，证实其通过稳定促转移基因RNA驱动侵袭表型。
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**注**：以上文献为示例，实际引用需检索PubMed等数据库获取真实信息，推荐关键词：`CIRBP antibody Western blot`、`CIRBP immunohistochemistry`。
CIRBP (Cold-inducible RNA-binding protein) is a stress-responsive protein belonging to the glycine-rich RNA-binding protein family. It plays a regulatory role in mRNA stability, translation, and splicing under cellular stress conditions such as hypothermia, hypoxia, or UV radiation. First identified as a cold-shock protein, CIRBP is constitutively expressed in various tissues but becomes upregulated during temperature drops (below 32°C) through post-transcriptional mechanisms. It interacts with specific RNA motifs to influence gene expression patterns critical for cell survival, proliferation, and adaptive responses.
CIRBP antibodies are essential tools for studying its expression dynamics, subcellular localization, and molecular interactions. They enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence. Research has linked CIRBP dysregulation to multiple pathological processes, including cancer progression (enhancing tumor cell survival and metastasis), neurodegenerative diseases, and inflammatory responses. Recent studies also explore its dual role as both a protective mediator in acute stress and a pathogenic driver in chronic conditions. Commercial CIRBP antibodies are typically raised against conserved epitopes in human or murine sequences, with validation across species. Ongoing research aims to clarify its context-dependent functions and therapeutic potential in stress-related disorders.
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