Rabbit Polyclonal UTP4 Antibody

The UTP4 antibody is a research tool designed to detect and study the UTP4 protein, a critical component of the small subunit (SSU) processome involved in ribosomal RNA (rRNA) biogenesis. UTP4. also known as Cirhin or CIRH1A, is a nucleolar protein that plays a role in the early stages of 18S rRNA processing. It interacts with other UTP (U3 small nucleolar RNA-associated protein) complex members to form a scaffold for ribosome assembly, ensuring proper rRNA folding and cleavage. Dysregulation of UTP4 has been linked to ribosomopathies and diseases such as North American Indian childhood cirrhosis (NAIC), caused by mutations in the CIRH1A gene. Researchers use UTP4 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions in cellular models. These studies help elucidate molecular mechanisms underlying ribosome biogenesis defects and their association with developmental disorders or cancer. The antibody’s specificity is typically validated using knockout controls or siRNA-mediated protein depletion. As ribosome dysfunction gains attention in biomedical research, UTP4 antibodies remain vital for exploring links between rRNA processing anomalies and human diseases.