| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DM2; ZNF9; CNBP1; PROMM; RNF163; ZCCHC22 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CNBP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于 **CNBP抗体** 的模拟参考文献(内容为虚构示例，供参考)：
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1. **文献名称**：*"CNBP Aggregation in Neurodegenerative Diseases: Antibody-Based Detection in ALS/FTD Models"*
**作者**：Smith J. et al. (2021)
**摘要**：研究利用特异性CNBP抗体在肌萎缩侧侧索硬化症(ALS)和额颞叶痴呆(FTD)患者脑组织中发现CNBP蛋白异常聚集，提示其在神经退行性疾病中可能通过RNA代谢失调驱动病理进程。
2. **文献名称**：*"Cellular Localization of CNBP in Stress Granules: A Role in Phase Separation"*
**作者**：Johnson R. et al. (2020)
**摘要**：通过免疫荧光和共聚焦显微镜技术，使用CNBP抗体揭示了该蛋白在细胞应激条件下参与应激颗粒(stress granules)的形成，并调控RNA-蛋白相分离过程的分子机制。
3. **文献名称**：*"CNBP Expression Profiling in Glioblastoma via Immunohistochemistry"*
**作者**：Lee H. et al. (2019)
**摘要**：采用CNBP特异性抗体对胶质母细胞瘤组织进行免疫组化分析，发现CNBP在肿瘤细胞中高表达，并与患者预后不良相关，可能作为潜在治疗靶点。
4. **文献名称**：*"Functional Characterization of CNBP Antibodies in Myotonic Dystrophy Models"*
**作者**：Brown K. et al. (2018)
**摘要**：研究通过Western blot和免疫沉淀验证了CNBP抗体在肌强直性营养不良模型中的特异性，证实CNBP与CAG重复RNA的异常结合导致肌肉细胞功能缺陷。
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(注：以上文献为示例性内容，实际研究中请通过PubMed或Google Scholar检索真实文献。)
The CNBP antibody targets the Cellular Nucleic Acid Binding Protein (CNBP), also known as zinc finger protein 9 (ZNF9), a highly conserved protein encoded by the CNBP gene. CNBP is a single-stranded nucleic acid-binding protein containing seven zinc knuckles, which facilitate interactions with DNA and RNA. It plays a regulatory role in transcription and translation, influencing processes such as ribosomal RNA synthesis, mRNA stability, and translational control. CNBP is implicated in cellular proliferation, differentiation, and apoptosis, with roles in embryonic development and tissue homeostasis.
Research highlights its association with neuromuscular disorders, particularly myotonic dystrophy type 2 (DM2), where abnormal CCTG repeat expansions in the CNBP gene disrupt RNA processing. Antibodies against CNBP are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CNBP's involvement in diseases, including neurodegeneration, cancer, and muscle atrophy. Recent studies also explore its potential role in RNA granule dynamics and stress response pathways. Despite progress, the precise molecular mechanisms of CNBP remain under investigation, underscoring the importance of specific antibodies for ongoing research.
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