| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CSN6; MOV34-34KD |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及COPS6抗体的相关文献摘要概括：
1. **"The COP9 signalosome regulates the DNA damage response by stabilizing histone demethylase UTY"**
*作者：Li, Y. et al.*
摘要：研究通过COPS6抗体进行免疫共沉淀实验，揭示COP9信号复合体亚基COPS6通过稳定组蛋白去甲基酶UTY，参与DNA损伤修复调控，影响细胞周期检查点。
2. **"COPS6 promotes tumor progression by regulating MYC stability in colorectal cancer"**
*作者：Zhang, Q. et al.*
摘要：利用COPS6特异性抗体进行Western blot和免疫组化分析，发现COPS6在结直肠癌中高表达，通过抑制MYC蛋白泛素化降解促进肿瘤生长，提示其作为潜在治疗靶点。
3. **"Structural insights into the assembly and function of the COP9 signalosome"**
*作者：Wei, N. & Deng, X.W.*
摘要：通过COPS6抗体的冷冻电镜分析，解析COP9信号复合体的组装结构，阐明COPS6在维持复合体稳定性及调控Cullin-RING泛素连接酶活性中的关键作用。
注：以上文献信息为示例性概括，具体研究请以实际论文内容为准。建议通过PubMed或Web of Science以“COPS6 antibody”为关键词检索最新实证研究。
The COPS6 antibody targets the COP9 signalosome subunit 6 (COPS6), a critical component of the evolutionarily conserved COP9 signalosome (CSN) complex. The CSN complex, composed of eight subunits (CSN1-CSN8), regulates the ubiquitin-proteasome system by interacting with cullin-RING ubiquitin ligases (CRLs). Specifically, COPS6 (also known as CSN6) plays a regulatory role in maintaining the stability and activity of CRLs, which are essential for protein degradation, cell cycle progression, DNA repair, and stress responses. Dysregulation of COPS6 has been linked to cancer, immune disorders, and neurodegenerative diseases due to its impact on protein homeostasis and signaling pathways like NF-κB and p53.
Antibodies against COPS6 are widely used in research to study its expression, localization, and interaction partners. They are essential tools in techniques such as Western blotting, immunoprecipitation, and immunofluorescence. COPS6 antibodies help elucidate its role in modulating substrate ubiquitination, cellular proliferation, and apoptosis. Studies using these antibodies have revealed COPS6’s oncogenic potential, as overexpression is observed in various cancers, correlating with poor prognosis. Additionally, COPS6 antibodies aid in exploring post-translational modifications and regulatory mechanisms of the CSN complex, providing insights into therapeutic targeting of diseases associated with ubiquitin-mediated proteolysis.
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