Rabbit Polyclonal COPS8 Antibody

The COPS8 antibody is a tool used to detect the COP9 signalosome subunit 8 (COPS8), a key component of the evolutionarily conserved COP9 signalosome (CSN) complex. The CSN is a multiprotein complex involved in regulating protein degradation via the ubiquitin-proteasome system, primarily by controlling the activity of cullin-RING ubiquitin ligases (CRLs). COPS8. also known as CSN8. is one of eight subunits (CSN1–CSN8) that form the CSN structure, which shares architectural similarities with the 26S proteasome. It plays a critical role in maintaining complex stability, facilitating deneddylation of cullin proteins, and modulating cellular processes such as DNA repair, cell cycle progression, and stress responses. Antibodies targeting COPS8 are utilized in research to study its expression, localization, and interactions in various biological contexts, including cancer, neurodegenerative diseases, and immune regulation. Dysregulation of COPS8 has been linked to tumorigenesis and developmental defects, highlighting its importance in cellular homeostasis. Western blotting, immunohistochemistry, and immunofluorescence are common applications for COPS8 antibodies, aiding in mechanistic studies of CSN-mediated pathways and potential therapeutic targeting.