| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | STL2; COLL6; CO11A1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human COL11A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及COL11A1抗体的代表性文献摘要(部分为模拟示例，实际文献需根据数据库检索确认)：
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1. **文献名称**: *Collagen XI α1 chain-mediated interaction with cancer cells promotes metastasis*
**作者**: Wu T, et al.
**摘要**: 研究利用COL11A1抗体进行免疫组化，发现其在胰腺癌基质中高表达，并与肿瘤细胞侵袭转移相关，提示COL11A1可能通过重塑细胞外基质促进癌症进展。
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2. **文献名称**: *COL11A1 as a biomarker in pulmonary fibrosis*
**作者**: Sato Y, et al.
**摘要**: 通过Western blot和免疫荧光技术，使用COL11A1抗体检测肺纤维化患者样本，发现其表达水平与纤维化程度正相关，可能成为治疗靶点。
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3. **文献名称**: *COL11A1 mutations and skeletal dysplasia: Antibody-based functional analysis*
**作者**: Hicks J, et al.
**摘要**: 研究利用COL11A1特异性抗体对小鼠模型进行组织染色，揭示突变导致胶原纤维结构异常，解释了COL11A1在骨骼发育中的作用及突变相关疾病的机制。
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**备注**：以上为基于领域知识的模拟示例，实际文献需通过PubMed/Google Scholar检索关键词“COL11A1 antibody”或“COL11A1 immunohistochemistry”获取。建议结合具体研究目的筛选近年高影响力论文。
The COL11A1 antibody targets collagen type XI alpha 1 chain, a component of type XI collagen, which belongs to the fibrillar collagen family. COL11A1 plays a critical role in regulating the assembly and organization of extracellular matrices, particularly in developing tissues, cartilage, and bone. It is expressed during embryogenesis and in certain pathological conditions, including fibrosis, osteoarthritis, and cancer. In cancer research, COL11A1 is implicated in tumor-stroma interactions, epithelial-mesenchymal transition (EMT), and metastasis, with overexpression observed in carcinomas of the breast, lung, and pancreas, often correlating with poor prognosis.
COL11A1 antibodies are widely used in immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting (WB) to study its spatial expression, tissue remodeling, and disease mechanisms. These antibodies help identify COL11A1's involvement in maintaining structural integrity and signaling in stromal fibroblasts or cancer-associated fibroblasts (CAFs). Additionally, they aid in exploring its role in rare genetic disorders like Marshall syndrome and Stickler syndrome, where COL11A1 mutations cause craniofacial and skeletal abnormalities. Recent studies also highlight its potential as a therapeutic target or biomarker for stromal targeting strategies. Researchers prioritize antibodies with high specificity due to structural similarities among collagen family members.
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