Rabbit Polyclonal CNN2 Antibody

CNN2 antibody targets calponin-2. a protein belonging to the calponin family, which regulates actin cytoskeleton dynamics and cellular contractility. Calponin-2 (CNN2) is expressed in smooth muscle cells, fibroblasts, and various non-muscle tissues, playing roles in cell motility, adhesion, and mechanotransduction. Unlike calponin-1 (CNN1), which is smooth muscle-specific, CNN2 has broader tissue distribution and is implicated in pathological processes such as fibrosis, cancer metastasis, and cardiovascular diseases. Research on CNN2 antibodies primarily focuses on elucidating its function in cytoskeletal remodeling, particularly in modulating actin filament stability and cell migration. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study CNN2 expression patterns in normal and diseased tissues. Recent studies highlight CNN2's involvement in tumor progression, where its upregulation correlates with enhanced invasive potential in cancers like breast and colorectal carcinoma. Additionally, CNN2 antibodies aid in exploring its role in vascular remodeling and inflammation, offering insights into therapeutic targeting. The development of specific, high-affinity CNN2 antibodies remains critical for advancing mechanistic studies and validating its potential as a biomarker or therapeutic target in diverse pathologies.