| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LDLC |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human COG2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于COG2抗体的3篇参考文献示例(内容基于公开文献概括，非真实引用)：
1. **文献名称**：*"COG complex subunits selectively regulate Golgi trafficking and glycosylation"*
**作者**：Smith A, et al.
**摘要**：研究利用COG2抗体通过免疫沉淀和免疫荧光技术，揭示了COG2在维持高尔基体结构和调控糖基化酶定位中的关键作用，其缺失导致蛋白质糖基化异常。
2. **文献名称**：*"Functional analysis of COG2 deficiency in a congenital disorder of glycosylation model"*
**作者**：Lee B, et al.
**摘要**：通过COG2抗体检测患者成纤维细胞中的蛋白表达，发现COG2缺失导致高尔基体运输功能紊乱，并引发II型先天性糖基化疾病(CDG-II)相关表型。
3. **文献名称**：*"COG2 interacts with STX5 to mediate retrograde vesicle transport in the Golgi"*
**作者**：Zhang Y, et al.
**摘要**：利用COG2抗体进行共免疫沉淀实验，证明COG2与SNARE蛋白STX5直接结合，调控高尔基体逆向囊泡运输，影响细胞分泌途径。
(注：以上为模拟示例，实际文献需通过数据库如PubMed检索确认。)
The COG2 antibody is a research tool used to study the Conserved Oligomeric Golgi (COG) complex, a critical multi-subunit protein assembly involved in intracellular trafficking and Golgi apparatus maintenance. The COG complex, comprising eight subunits (COG1-8), regulates vesicle tethering, glycosylation, and retrograde transport within the Golgi. COG2 (component of oligomeric Golgi complex subunit 2), encoded by the *COG2* gene, is part of the COG1-4 subcomplex and plays a pivotal role in maintaining Golgi structure and function. Defects in COG2 disrupt glycosylation enzymes' localization, impairing protein and lipid glycosylation—a hallmark of congenital disorders of glycosylation (CDGs).
COG2-specific antibodies are essential for detecting COG2 protein expression, localization, and interactions in cellular models. Researchers use these antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate COG2's role in Golgi dynamics and disease mechanisms. Mutations in *COG2* are linked to CDG type II (e.g., COG2-CDG), characterized by neurological and developmental abnormalities. Studying COG2 via its antibody helps elucidate molecular pathways in glycosylation disorders and potential therapeutic targets. Commercial COG2 antibodies are typically raised in rabbits or mice, validated for specificity, and widely used in cell biology and clinical research contexts.
×
