Rabbit Polyclonal CNOT2 Antibody

The CNOT2 antibody is a research tool used to detect CNOT2. a critical subunit of the CCR4-NOT complex, which plays versatile roles in gene expression regulation. CNOT2 (CCR4-NOT Transcription Complex Subunit 2) acts as a scaffolding protein to stabilize the multi-subunit CCR4-NOT complex, facilitating interactions with other components like CNOT1. CNOT3. and deadenylases. This complex is involved in mRNA deadenylation, decay, and translational repression, thereby modulating post-transcriptional processes. CNOT2 also participates in transcriptional regulation by interacting with nuclear receptors and chromatin modifiers. Dysregulation of CNOT2 has been linked to cancer, neurological disorders, and developmental defects due to its role in cell cycle control, stress responses, and maintaining cellular homeostasis. Antibodies targeting CNOT2 are widely employed in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to study its expression, localization, and interactions. They are essential for exploring CNOT2's molecular mechanisms in cellular processes and disease models. Validated CNOT2 antibodies typically demonstrate specificity through knockout controls, enabling reliable detection in diverse experimental systems. Research utilizing these antibodies has advanced understanding of mRNA metabolism, protein synthesis, and CCR4-NOT-mediated regulatory networks.