| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CPNE7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CPNE7抗体的参考文献示例(内容为模拟，建议核实具体文献)：
1. **文献名称**：*CPNE7 Promotes Odontoblastic Differentiation via BMP Signaling in Dental Pulp Stem Cells*
**作者**：Kim S, et al.
**摘要**：本研究利用CPNE7抗体检测其在牙髓干细胞中的表达，发现CPNE7通过激活BMP/Smad通路调控成牙本质分化，为牙本质再生治疗提供潜在靶点。
2. **文献名称**：*CPNE7 as a Novel Biomarker in Oral Squamous Cell Carcinoma: Immunohistochemical Analysis*
**作者**：Lee JH, et al.
**摘要**：通过免疫组化(CPNE7抗体)分析口腔鳞癌组织中CPNE7的表达水平，发现其高表达与肿瘤侵袭性相关，提示其作为预后标志物的可能性。
3. **文献名称**：*Role of CPNE7 in Neuronal Development: Insights from Knockdown Models*
**作者**：Park M, et al.
**摘要**：研究采用CPNE7抗体进行蛋白质定位，发现CPNE7在小鼠海马神经元突触形成中起关键作用，其缺失导致突触可塑性异常。
4. **文献名称**：*CPNE7-Mediated Extracellular Vesicle Communication in Cancer Metastasis*
**作者**：Chen L, et al.
**摘要**：通过Western blot(CPNE7抗体)和质谱分析，揭示CPNE7通过调控外泌体分泌促进肿瘤细胞转移的分子机制。
**注意**：以上文献为示例，实际引用时请通过PubMed、Google Scholar等平台检索最新研究，并核对作者及摘要准确性。
The CPNE7 antibody targets Copine-7 (CPNE7), a calcium-dependent phospholipid-binding protein belonging to the copine family, which regulates membrane trafficking, signaling, and cellular adhesion. Structurally, CPNE7 contains two N-terminal C2 domains that mediate calcium-dependent membrane binding and a C-terminal von Willebrand factor A (vWA) domain implicated in protein interactions. It is expressed in various tissues, including the brain, kidney, and immune cells, and plays roles in cell differentiation, neuronal development, and tissue regeneration. Dysregulation of CPNE7 has been linked to cancers, neurodegenerative disorders, and inflammatory conditions, highlighting its potential as a therapeutic or diagnostic target.
CPNE7 antibodies are widely used in research to detect CPNE7 expression and localization via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They also help study CPNE7's interactions with signaling molecules, such as integrins or growth factor receptors, and its role in calcium-mediated pathways. Recent studies suggest CPNE7 may influence tumor progression by modulating metastasis-related pathways, making its antibody a valuable tool in oncology research. Additionally, in dental biology, CPNE7 is associated with odontoblast differentiation and dentin formation, expanding its relevance in regenerative medicine. Commercial CPNE7 antibodies are typically validated for specificity and sensitivity, though performance may vary across applications. Ongoing research aims to clarify its mechanistic roles and therapeutic potential.
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