| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DCP1 |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human DCP1B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DCP1B抗体的模拟参考文献示例(实际文献需通过学术数据库查询)：
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1. **文献名称**：*"DCP1B is a critical component of the mRNA decapping complex required for 5'-3' degradation"*
**作者**：Smith J, et al.
**摘要**：本研究利用特异性DCP1B抗体，证实了DCP1B与脱帽酶复合物其他成员(如DCP1A、DCP2)的相互作用，并通过免疫沉淀实验揭示其在mRNA降解中的功能。抗体验证显示其在哺乳动物细胞中特异性识别内源性DCP1B蛋白。
2. **文献名称**：*"Dynamic localization of DCP1B in cytoplasmic granules under stress conditions"*
**作者**：Zhang Y, et al.
**摘要**：通过免疫荧光技术结合DCP1B抗体，作者发现DCP1B在氧化应激条件下聚集于细胞质应激颗粒(stress granules)，提示其可能参与mRNA代谢的应激调控途径。
3. **文献名称**：*"Development and validation of a polyclonal antibody against human DCP1B for functional studies"*
**作者**：Lee S, et al.
**摘要**：本文报道了一种针对人源DCP1B的多克隆抗体的开发，通过Western blot和免疫组化验证其特异性，并应用于基因敲除模型中，证明DCP1B在胚胎发育中的重要作用。
4. **文献名称**：*"DCP1B promotes tumor progression via mRNA decay pathways in colorectal cancer"*
**作者**：Wang H, et al.
**摘要**：利用DCP1B抗体进行组织芯片分析，发现DCP1B在结直肠癌中高表达，并通过调控特定mRNA的稳定性影响癌细胞增殖和转移。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台以关键词“DCP1B antibody”或“DCP1B function”检索。若需具体文献，建议结合实验背景进一步筛选。
The DCP1B antibody is a tool used to detect and study the Decapping mRNA 1B (DCP1B) protein, a key component of the mRNA decapping complex involved in post-transcriptional gene regulation. DCP1B, along with DCP1A, facilitates mRNA degradation by removing the 5' cap structure, a critical step in controlling mRNA stability and turnover. This process is essential for regulating gene expression, particularly in response to cellular stress, developmental cues, or environmental changes.
DCP1B is implicated in diverse cellular functions, including cell cycle progression, apoptosis, and differentiation. Dysregulation of mRNA decapping has been linked to diseases such as cancer, neurodegenerative disorders, and viral infections. Researchers utilize DCP1B antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions within cellular pathways. These studies aim to uncover its role in maintaining mRNA homeostasis and its potential as a therapeutic target. Commercial DCP1B antibodies are typically validated for specificity and sensitivity, though performance may vary depending on epitope accessibility and experimental conditions. Ongoing research continues to explore DCP1B's regulatory mechanisms and its broader impact on cellular physiology and disease pathology.
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