| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于GK5抗体的虚构参考文献示例(内容基于假设性研究构建)：
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1. **文献名称**：*"GK5 Antibody Inhibits Tumor Growth by Targeting PI3K/AKT Pathway in Colorectal Cancer"*
**作者**：Chen L. et al.
**摘要**：本研究证明GK5抗体通过特异性结合PI3K/AKT通路中的关键蛋白GK5.显著抑制结直肠癌细胞增殖并诱导凋亡，动物模型显示其可减少肿瘤体积且无显著毒性。
2. **文献名称**：*"Development of a High-Specificity GK5 Monoclonal Antibody for Neurodegenerative Disease Diagnosis"*
**作者**：Rodriguez S. et al.
**摘要**：团队开发了一种高特异性抗GK5单克隆抗体，可精准检测阿尔茨海默病患者脑脊液中的GK5异常聚集，为早期诊断提供新型生物标志物检测工具。
3. **文献名称**：*"GK5 Antibody-Mediated Blockade Attenuates Cardiac Hypertrophy in Hypertensive Rats"*
**作者**：Wang Y. et al.
**摘要**：实验表明，GK5抗体通过阻断心肌细胞中GK5与钙调蛋白的相互作用，减轻高血压模型大鼠的心肌肥厚，提示其作为心力衰竭治疗的潜在靶点。
4. **文献名称**：*"Structural Characterization of GK5 Epitopes Using Phage Display and Cryo-EM"*
**作者**：Kumar A. et al.
**摘要**：结合噬菌体展示和冷冻电镜技术，解析了GK5抗体的抗原表位结构，揭示其与GK5蛋白C端结构域的特异性结合机制，为抗体优化提供结构基础。
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注：以上文献为示例性内容，实际引用时需以真实发表的论文为准。如需查找真实文献，建议通过PubMed、Google Scholar等平台检索关键词“GK5 antibody”或“GK5 protein”。
The GK5 antibody targets the G protein-coupled receptor kinase 5 (GRK5), a serine/threonine kinase involved in regulating G protein-coupled receptor (GPCR) signaling. GRK5 phosphorylates activated GPCRs, promoting receptor desensitization and internalization, thus modulating cellular responses to hormones, neurotransmitters, and external stimuli. It plays critical roles in cardiovascular function, cell proliferation, and immune regulation. Dysregulation of GRK5 is linked to pathologies such as heart failure, cancer, and inflammatory diseases.
The GK5 antibody is widely used in research to study GRK5 expression, localization, and function in tissues and cell lines. It enables detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies utilizing this antibody have revealed GRK5's dual role in disease: while its overexpression in heart tissue exacerbates hypertrophy, its downregulation in certain cancers correlates with tumor progression.
Recent research highlights GRK5's potential as a therapeutic target, particularly in heart disease and oncology. The GK5 antibody serves as a key tool for validating experimental models, screening drug candidates, and elucidating GRK5-dependent signaling pathways. Its specificity and reliability make it essential for advancing understanding of GPCR-related mechanisms and developing targeted therapies.
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