| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EIF2; EIF2B; PPP1R67; EIF2beta; eIF-2-beta |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human EIF2S2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **EIF2S2抗体** 的3篇参考文献(均为虚拟示例，供参考)：
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1. **文献名称**：*EIF2S2 as a Biomarker in Triple-Negative Breast Cancer: Expression and Functional Analysis*
**作者**：Li, X. et al.
**摘要**：研究通过免疫组化(使用EIF2S2特异性抗体)发现EIF2S2在乳腺癌组织中高表达，并通过敲低实验证明其促进肿瘤细胞增殖和转移的机制，提示其作为治疗靶点的潜力。
2. **文献名称**：*Role of EIF2S2 in Viral Infection-Induced Translational Control*
**作者**：Smith, J. & García-Romero, M.T.
**摘要**：利用EIF2S2抗体进行Western blot和免疫荧光分析，揭示病毒感染后EIF2S2磷酸化水平的变化，阐明其在宿主抗病毒翻译调控中的作用。
3. **文献名称**：*EIF2S2 Antibody Validation for Neuronal Stress Response Studies*
**作者**：Chen, H. et al.
**摘要**：通过比较多种EIF2S2抗体在神经元细胞中的特异性，验证了某商业抗体在检测内源性EIF2S2蛋白表达及亚细胞定位中的可靠性，为神经退行性疾病研究提供工具支持。
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**注**：以上文献为模拟示例，实际研究中请通过PubMed或Google Scholar以关键词“EIF2S2 antibody” + 研究领域(如癌症、病毒、神经科学等)检索最新文献。
The EIF2S2 antibody targets the eukaryotic translation initiation factor 2 subunit beta (EIF2S2), a critical component of the eIF2 complex involved in protein synthesis initiation. EIF2S2. also known as eIF2β, plays a regulatory role in the formation of the ternary complex (eIF2-GTP-Met-tRNAi), which is essential for ribosome recruitment during translation. This subunit facilitates GTP binding and modulates eIF2 activity through interactions with other initiation factors and regulatory kinases. Dysregulation of EIF2S2 or the eIF2 complex is implicated in cellular stress responses, including the integrated stress response (ISR), which adjusts protein synthesis under conditions like nutrient deprivation, viral infection, or endoplasmic reticulum stress.
Antibodies against EIF2S2 are widely used in research to investigate translational control mechanisms, cellular stress pathways, and diseases linked to eIF2 dysfunction, such as neurodegenerative disorders, cancer, and metabolic syndromes. They enable detection of EIF2S2 expression, post-translational modifications (e.g., phosphorylation), and interactions in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Studies using these antibodies have also explored the role of EIF2S2 in viral replication, where host translation machinery is hijacked, and in therapeutic contexts targeting stress-adaptive pathways. Their specificity and reliability make EIF2S2 antibodies vital tools for unraveling translational regulation in health and disease.
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