| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DIM1; DIMT1L; HUSSY5; HSA9761 |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DIMT1抗体的3篇示例参考文献(内容为虚构示例，仅供参考)：
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1. **文献名称**: *DIMT1 regulates mitochondrial apoptosis in cancer cells via rRNA modification*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用DIMT1特异性抗体，通过Western blot和免疫组化技术，揭示了DIMT1通过调控18S rRNA的甲基化修饰影响线粒体凋亡通路，抑制DIMT1表达可增强化疗药物诱导的肿瘤细胞死亡。
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2. **文献名称**: *Developmental role of DIMT1 in mouse embryogenesis*
**作者**: Chen L, et al.
**摘要**: 通过DIMT1抗体进行组织特异性定位分析，发现DIMT1在小鼠胚胎早期发育中高表达，敲除后导致心脏和神经系统发育异常，提示其参与核糖体生物合成及细胞增殖调控。
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3. **文献名称**: *DIMT1 interacts with p53 to modulate oxidative stress response*
**作者**: Lee S, et al.
**摘要**: 使用DIMT1抗体进行免疫共沉淀实验，证实DIMT1与p53蛋白直接结合，协同调控下游抗氧化基因表达，缺失DIMT1的细胞对氧化应激敏感性显著升高。
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注：以上文献为示例，实际研究中请通过PubMed或Google Scholar以关键词“DIMT1 antibody”或“DIMT1 function”检索真实发表的论文。
The DIMT1 (Disturbance of Meiotic Telomeres 1) antibody is a research tool used to detect and study the DIMT1 protein, a conserved eukaryotic protein implicated in ribosome biogenesis and cellular stress responses. DIMT1. originally identified in yeast (as Rlp24) and later in mammals, plays a critical role in the maturation of the large ribosomal subunit by facilitating the assembly of rRNA and ribosomal proteins. It is localized to the nucleolus and participates in the pseudouridylation of rRNA, a modification essential for ribosome stability and function.
Studies suggest DIMT1 is involved in regulating cell proliferation, differentiation, and apoptosis. Its dysregulation has been linked to cancer progression, neurodegenerative diseases, and developmental disorders. For instance, elevated DIMT1 expression has been observed in certain cancers, correlating with poor prognosis. In neuroscience, DIMT1 interacts with stress granule components, indicating a role in cellular adaptation to stress.
The DIMT1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze protein expression, subcellular localization, and interactions. It aids in elucidating DIMT1's molecular mechanisms in ribosome biogenesis, stress signaling, and disease pathways. Ongoing research continues to explore its potential as a therapeutic target or biomarker, emphasizing its importance in both basic and translational biomedical studies.
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