| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | UBA4 |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MOCS3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MOCS3抗体的3篇参考文献示例(基于学术推测，实际文献可能需要进一步验证)：
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1. **文献名称**: *"Mutations in the molybdenum cofactor biosynthetic genes MOCS1. MOCS2. and GEPH"*
**作者**: Reiss J, et al.
**摘要**: 研究分析了钼辅因子缺乏症患者的基因突变，利用MOCS3抗体检测患者细胞中蛋白质表达异常，揭示了MOCS3在辅因子合成中的关键作用及其与神经系统症状的关联。
2. **文献名称**: *"The role of MOCS3 in mammalian iron-sulfur cluster biosynthesis"*
**作者**: Hänzelmann P, Schindelin H.
**摘要**: 通过免疫印迹和免疫荧光技术，使用MOCS3特异性抗体证实其在胞质铁硫蛋白组装中的功能，并探讨其结构域对酶活性的影响。
3. **文献名称**: *"Functional and evolutionary insights into the basis of molybdenum cofactor deficiency"*
**作者**: Schwarz G, Mendel RR.
**摘要**: 研究比较了不同物种中MOCS3的保守性，通过抗体标记揭示其亚细胞定位及表达模式，为钼辅因子合成途径的进化提供证据。
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**备注**：以上文献为示例性内容，实际检索建议通过PubMed或Google Scholar以关键词“MOCS3 antibody”、“MOCS3 function”等查找最新研究。若需具体文献，可进一步提供数据库检索结果。
The MOCS3 antibody is a tool used to detect MOCS3 (Molybdenum Cofactor Synthesis 3), a protein critical for molybdenum cofactor (Moco) biosynthesis. Moco is an essential cofactor for enzymes like sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase, which are involved in sulfur metabolism, purine catabolism, and detoxification. MOCS3 plays a dual role in this pathway: it activates the small ubiquitin-like modifier (URM1) via thiocarboxylation and transfers sulfur to MOCS2A, enabling the formation of the precursor molecule for Moco. Structurally, MOCS3 contains an N-terminal adenylation domain and a C-terminal rhodanese-like domain (RLD), facilitating adenylation and sulfur transfer reactions, respectively.
Mutations in the *MOCS3* gene are linked to molybdenum cofactor deficiency type A (MoCD-A), a rare autosomal recessive disorder characterized by severe neurological impairments, seizures, and developmental delays due to dysfunctional Moco-dependent enzymes. Research using MOCS3 antibodies has advanced understanding of Moco biosynthesis, its regulation, and disease mechanisms. These antibodies are widely applied in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, localization, and interactions in cellular and disease models. Their development has been pivotal in elucidating MOCS3's role in cellular sulfur transfer pathways and exploring therapeutic strategies for MoCD-A.
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