| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IR10; WDR2; CLIPINB |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CORO2A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CORO2A抗体的示例参考文献(内容为虚构示例，仅供参考)：
1. **文献名称**: "Characterization of a novel monoclonal antibody against human Coronin 2A (CORO2A) for immune cell studies"
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种针对人CORO2A蛋白的单克隆抗体，并通过Western blot和免疫荧光验证其特异性。抗体成功应用于检测T淋巴细胞中CORO2A的表达与亚细胞定位，证实其在免疫突触形成中的作用。
2. **文献名称**: "CORO2A regulates actin cytoskeleton dynamics in cancer metastasis: an antibody-based functional analysis"
**作者**: Lee S, et al.
**摘要**: 通过使用商业化CORO2A抗体(货号ABX-123)，作者揭示了CORO2A在乳腺癌细胞迁移中对肌动蛋白重塑的调控机制，抗体用于免疫组化分析临床样本中CORO2A的表达与预后的相关性。
3. **文献名称**: "Development of polyclonal anti-CORO2A antibodies and their application in neuronal development models"
**作者**: Garcia R, et al.
**摘要**: 本研究制备了兔源多克隆CORO2A抗体，验证其在小鼠脑组织中的反应性，并发现CORO2A在海马神经元突触发育中的关键作用，抗体用于免疫沉淀和共聚焦显微镜分析。
4. **文献名称**: "CORO2A in macrophage phagocytosis: insights from antibody-mediated knockdown experiments"
**作者**: Wang Y, et al.
**摘要**: 利用CORO2A特异性抗体进行功能阻断实验，证明CORO2A通过调控F-actin组装促进巨噬细胞对病原体的吞噬作用，抗体应用于流式细胞术和活细胞成像分析。
(注：以上文献为模拟示例，实际研究中请通过PubMed、Google Scholar等平台检索真实发表文章。)
The CORO2A antibody is a research tool designed to detect and analyze coronin 2A (CORO2A), a member of the coronin protein family involved in regulating cytoskeletal dynamics, cell motility, and intracellular signaling. Coronins are characterized by their conserved WD40-repeat domains, which facilitate protein-protein interactions. CORO2A, also known as ClipinB or Coronin-like protein B, is distinct from other coronin family members due to its nuclear localization and role in modulating actin polymerization, vesicle trafficking, and transcriptional regulation. It interacts with components such as the ARP2/3 complex and cofilin to influence actin remodeling, critical for processes like immune cell migration and neuronal development.
CORO2A antibodies are widely used in immunoblotting (Western blot), immunofluorescence, and immunohistochemistry to study CORO2A expression patterns, subcellular distribution, and functional roles in physiological and pathological contexts. Research has linked CORO2A dysregulation to cancer progression, immune disorders, and neurodegenerative diseases, making it a biomarker of interest. For example, elevated CORO2A levels are observed in certain cancers, where it may promote invasiveness by enhancing metastatic cell motility. Antibody specificity is typically validated via knockout controls or siRNA-mediated silencing. Researchers prioritize antibodies with high affinity, minimal cross-reactivity to homologous coronins (e.g., CORO1A, CORO1B), and consistent performance across experimental models (human, mouse, rat). Reliable CORO2A antibodies are essential for elucidating its molecular mechanisms and therapeutic potential.
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