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Rabbit Polyclonal KCNS3 Antibody

  • 中文名: KCNS3抗体
  • 别    名: KV9.3
货号: IPDX09756
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesKV9.3
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human KCNS3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于KCNS3抗体的3篇虚构参考文献示例(注意:实际文献需通过学术数据库检索):

1. **标题**:*KCNS3 Expression in Neuropathic Pain Models*

**作者**:Mazzitelli, J. et al. (2021)

**摘要**:研究通过免疫组化技术结合KCNS3特异性抗体,发现KCNS3在脊髓背角神经元中的表达显著上调,提示其在慢性疼痛信号传导中的潜在调控作用。

2. **标题**:*KCNS3 as a Prognostic Marker in Glioblastoma*

**作者**:Verkhratsky, A. & Rodríguez, L. (2019)

**摘要**:利用KCNS3抗体进行蛋白质印迹分析,发现胶质母细胞瘤患者肿瘤组织中KCNS3蛋白水平与患者生存率呈负相关,可能与肿瘤细胞异常电活动相关。

3. **标题**:*KCNS3 Antibody Validation for Epilepsy Research*

**作者**:Chen, H. et al. (2020)

**摘要**:通过KCNS3抗体验证其在海马体神经元中的特异性表达,并发现癫痫模型中KCNS3表达下调,表明其可能影响钾通道功能及神经元兴奋性。

4. **标题**:*Epigenetic Regulation of KCNS3 in Schizophrenia*

**作者**:Smith, R. & Patel, K. (2022)

**摘要**:研究结合KCNS3抗体检测及DNA甲基化分析,发现精神分裂症患者前额叶皮层中KCNS3表达受表观遗传抑制,可能参与认知功能异常机制。

**注意**:以上文献为示例性质,实际研究需通过PubMed、Google Scholar等平台检索关键词“KCNS3 antibody”获取真实文献。

背景信息

The KCNS3 antibody targets the KCNS3 protein, encoded by the potassium voltage-gated channel modifier subfamily S member 3 gene (*KCNS3*). This protein belongs to the voltage-gated potassium (Kv) channel family, specifically the "silent" or regulatory alpha subunit subgroup, which modulates the activity of pore-forming Kv subunits. KCNS3 regulates neuronal excitability, impacting action potential duration and neurotransmitter release. It is predominantly expressed in the nervous system but is also found in other tissues. Research on KCNS3 antibodies focuses on understanding its role in neurological disorders (e.g., epilepsy, chronic pain) and cancer, where altered expression correlates with disease progression. For instance, KCNS3 overexpression in certain tumors has been linked to poor prognosis. Antibodies against KCNS3 enable detection of protein localization, expression levels, and interactions in experimental models, aiding mechanistic studies. However, challenges persist due to the protein's structural diversity from alternative splicing and post-translational modifications, requiring antibody specificity validation. KCNS3 remains a potential therapeutic target, with ongoing studies exploring its pathophysiological contributions and utility as a biomarker.

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