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Rabbit Polyclonal COG4 Antibody

  • 中文名: COG4抗体
  • 别    名: COD1; CDG2J
货号: IPDX09769
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesSRC2; c-fgr; c-src2; p55c-fgr; p58c-fgr
Entrez GeneID2268
clone6G2
WB Predicted band size56kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human FGR expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于COG4抗体的参考文献示例(注:以下内容基于模拟生成,可能需要根据实际文献调整):

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1. **文献名称**: *COG4 mutations lead to defective glycosylation and impaired Golgi function*

**作者**: Smith J, et al.

**摘要**: 该研究通过COG4抗体进行免疫印迹和免疫荧光实验,发现COG4基因突变导致患者细胞中高尔基体结构异常,影响糖蛋白修饰过程,揭示了COG复合体在糖基化中的关键作用。

2. **文献名称**: *The role of the COG complex in vesicle trafficking and Golgi maintenance*

**作者**: Lee S, et al.

**摘要**: 利用COG4特异性抗体抑制其功能,发现COG4缺失破坏高尔基体-内质网逆向运输,导致膜泡运输障碍,表明COG4在维持高尔基体稳态中不可或缺。

3. **文献名称**: *Interaction mapping of COG complex subunits using co-immunoprecipitation*

**作者**: Zhang Y, et al.

**摘要**: 通过COG4抗体进行免疫共沉淀实验,鉴定了COG4与其他COG亚基(如COG1、COG2)的相互作用网络,为解析COG复合体组装机制提供证据。

4. **文献名称**: *COG4 antibody-based diagnostic approach for a congenital glycosylation disorder*

**作者**: Müller U, et al.

**摘要**: 研究开发了一种基于COG4抗体的ELISA检测方法,用于快速诊断由COG4缺陷引起的先天性糖基化疾病(CDG),并验证了其临床适用性。

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(注:上述文献为示例,实际引用需查询PubMed等数据库获取真实信息。)

背景信息

The COG4 antibody is a research tool targeting the COG4 protein, a critical subunit of the Conserved Oligomeric Golgi (COG) complex. The COG complex, composed of eight subunits (COG1-8), regulates vesicle trafficking and glycosylation within the Golgi apparatus. COG4. part of the COG1-4 subcomplex (lobe B), interacts with SNARE proteins and Rab GTPases to maintain Golgi structure and function. Mutations in COG4 are linked to congenital disorders of glycosylation (CDGs), particularly COG4-CDG (formerly CDG-IIj), characterized by developmental delays, hypotonia, and impaired protein glycosylation. COG4 antibodies enable detection and localization of COG4 in cells, aiding studies on Golgi dynamics, vesicular transport, and disease mechanisms. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate COG4's role in cellular homeostasis and pathology. Their development has advanced understanding of COG complex dysfunction in neurological disorders and metabolic diseases, highlighting COG4's essentiality in maintaining Golgi integrity and proper protein trafficking.

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