| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RSNL1; CLIPR59; CLIPR-59 |
| WB Predicted band size | 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CLIP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CLIP3抗体的3篇示例参考文献(注：以下为模拟内容，实际文献需根据具体数据库查询验证)：
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1. **文献名称**: *CLIP3 regulates tumor metastasis via cytoskeletal remodeling in invasive breast cancer*
**作者**: Lee, J. et al. (2016)
**摘要**: 本研究通过CLIP3特异性抗体进行免疫印迹和免疫荧光实验，发现CLIP3通过调控肌动蛋白动态重组促进乳腺癌细胞迁移和侵袭，为靶向CLIP3的癌症治疗提供理论依据。
2. **文献名称**: *Development of a novel monoclonal antibody against CLIP3 for diagnostic applications in colorectal cancer*
**作者**: Wang, Y. et al. (2019)
**摘要**: 文章报道了一种高特异性抗CLIP3单克隆抗体的开发，并验证其在结直肠癌组织中的诊断价值。实验表明，CLIP3在癌组织中显著高表达，与患者预后不良相关。
3. **文献名称**: *CLIP3 mediates autophagy-lysosomal pathway in neurodegenerative disorders*
**作者**: Chen, R. et al. (2021)
**摘要**: 利用CLIP3抗体进行脑组织免疫组化分析，揭示CLIP3通过调控自噬-溶酶体通路影响神经退行性疾病(如阿尔茨海默病)中异常蛋白的清除机制。
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**注意**：以上文献为示例，实际研究中请通过PubMed、Google Scholar等平台检索真实文献(关键词如“CLIP3 antibody”、“CLIP3 function”)。若需具体文献协助，请提供更多研究背景。
The CLIP3 antibody targets the CLIP3 protein (Cytoplasmic Linker Protein 3), also known as RSNL2 or CLIP-170-related protein, which plays a role in intracellular trafficking, membrane dynamics, and cytoskeletal organization. CLIP3 belongs to the CLIP family of proteins that interact with microtubules and regulate vesicle transport, cell polarization, and signal transduction. It contains a conserved N-terminal CAP-Gly domain for microtubule binding and a C-terminal region mediating interactions with other proteins or membranes.
CLIP3 is implicated in diverse cellular processes, including endocytosis, receptor recycling, and Wnt/β-catenin signaling. Studies suggest its involvement in cancer progression, where it may influence cell migration, invasion, and metastasis. For instance, CLIP3 overexpression has been linked to enhanced EGFR trafficking in glioblastoma and colorectal cancer. Its antibody is widely used in research to investigate these mechanisms via techniques like immunofluorescence, Western blotting, and co-immunoprecipitation.
The development of CLIP3 antibodies has advanced studies on its role in pathological conditions, particularly oncology and neurobiology. Researchers utilize these tools to explore CLIP3's potential as a biomarker or therapeutic target, given its regulatory effects on critical pathways. However, its functional diversity across tissues and contexts necessitates further investigation to clarify its precise molecular roles and clinical relevance.
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