| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Scml3 |
| WB Predicted band size | 73 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SCMH1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SCMH1抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
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1. **文献名称**: "SCMH1 is a novel polycomb group gene that regulates progenitor cell differentiation"
**作者**: Li Y, et al.
**摘要**: 本研究利用SCMH1特异性抗体进行染色质免疫沉淀(ChIP)和免疫荧光染色，发现SCMH1作为多梳蛋白家族成员，通过调控Hox基因的表达影响神经前体细胞的分化。抗体验证表明SCMH1在胚胎发育中广泛表达。
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2. **文献名称**: "The role of SCMH1 in maintaining stem cell pluripotency through chromatin remodeling"
**作者**: Zhang H, et al.
**摘要**: 通过Western blot和免疫共沉淀(Co-IP)实验，作者使用SCMH1抗体证明其与PRC1复合体相互作用，维持胚胎干细胞的自我更新能力。研究强调了SCMH1在表观遗传调控中的关键作用。
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3. **文献名称**: "SCMH1 deficiency leads to altered hematopoiesis and leukemia predisposition in mice"
**作者**: Wang X, et al.
**摘要**: 该研究利用SCMH1抗体进行组织特异性敲除小鼠模型的蛋白表达分析，发现SCMH1缺失导致造血干细胞异常增殖和白血病易感性增加，提示其在血液系统疾病中的潜在机制。
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注：以上文献信息为示例性内容，实际文献需通过PubMed或Google Scholar检索确认。若需具体文章，可提供更详细的研究方向或补充关键词进一步筛选。
The SCMH1 antibody targets the Suppressor of Combative Motor Protein Homolog 1 (SCMH1), a protein encoded by the *SCMH1* gene in humans. SCMH1 is a member of the Polycomb-group (PcG) protein family, which plays a critical role in epigenetic regulation by maintaining transcriptional repression of specific genes, particularly during development. It is a component of the Polycomb Repressive Complex 1 (PRC1), facilitating monoubiquitination of histone H2A (H2AK119ub) to stabilize chromatin compaction and silence target genes. SCMH1 is involved in diverse biological processes, including cell differentiation, stem cell maintenance, and axial patterning.
Antibodies against SCMH1 are primarily used in research to study its expression, localization, and functional interactions in cellular and developmental contexts. They are employed in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate SCMH1’s role in PRC1-mediated gene silencing and its implications in diseases such as cancers or neurodevelopmental disorders. These antibodies are typically raised in rabbits or mice, with validation including knockout cell lines or tissues to confirm specificity. Understanding SCMH1 dynamics via such antibodies contributes to elucidating PcG-mediated epigenetic mechanisms and their therapeutic potential.
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