Rabbit Polyclonal HSPA2 Antibody

The HSPA2 antibody targets the Heat Shock Protein Family A (HSP70) member 2. a chaperone protein critical for cellular stress response and protein homeostasis. HSPA2. also known as HSP70-2. is primarily expressed in germ cells and plays a vital role in spermatogenesis, facilitating meiotic processes and sperm maturation. It stabilizes client proteins, prevents aggregation under stress, and aids in folding or degrading misfolded proteins. Beyond reproductive biology, HSPA2 is implicated in cancer, where its overexpression in tumors like breast, lung, and colorectal cancer correlates with poor prognosis, potentially supporting cell survival and therapy resistance. In neurodegenerative diseases, HSPA2 may interact with pathogenic proteins (e.g., α-synuclein, tau), though its role here is less defined. Researchers use HSPA2 antibodies in techniques such as Western blot, immunohistochemistry, and immunofluorescence to study its expression, localization, and interactions. Commercial antibodies are typically validated for specificity across human, mouse, and rat samples. Understanding HSPA2's dual roles in physiological processes and disease mechanisms highlights its relevance as a biomarker or therapeutic target, driving ongoing studies in oncology, reproductive health, and neurodegeneration.