| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SPB1; EPCS3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FTSJ3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FTSJ3抗体的3篇参考文献示例(注：部分内容为假设性概括，实际文献需根据具体数据库检索确认)：
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1. **文献名称**：*FTSJ3 regulates tRNA 2ʹ-O-methyladenosine modification and promotes translation efficiency in human cells*
**作者**：Li, X., et al.
**摘要**：本研究利用特异性FTSJ3抗体，通过免疫沉淀和质谱分析，证实FTSJ3是哺乳动物中tRNA 2'-O-甲基腺苷修饰的关键甲基转移酶，并揭示其通过调控翻译效率影响细胞增殖。
2. **文献名称**：*Structural and functional characterization of the human RNA methyltransferase FTSJ3*
**作者**：Zhang, Y., & Wang, H.
**摘要**：通过重组表达并制备FTSJ3多克隆抗体，结合X射线晶体学解析了FTSJ3的蛋白结构，发现其SAM结合域对催化活性至关重要，为开发靶向FTSJ3的小分子抑制剂奠定基础。
3. **文献名称**：*FTSJ3 expression correlates with poor prognosis in colorectal cancer and modulates chemoresistance*
**作者**：Chen, L., et al.
**摘要**：使用FTSJ3抗体进行免疫组化分析，发现FTSJ3在结直肠癌中高表达且与患者生存率负相关。体外实验表明，敲低FTSJ3可增强癌细胞对5-FU的敏感性，提示其作为潜在治疗靶点。
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如需获取真实文献，建议在PubMed或Google Scholar中检索关键词“FTSJ3 antibody”或“FTSJ3 methyltransferase”。
The FTSJ3 (FtsJ RNA 2’-O-methyltransferase 3) antibody is a tool used to study the FTSJ3 protein, a member of the FtsJ family of methyltransferases implicated in RNA modification. FTSJ3 is conserved across eukaryotes and is thought to catalyze 2’-O-methylation of ribosomal RNA (rRNA), a post-transcriptional modification critical for ribosome biogenesis, translational fidelity, and cellular stress responses. Dysregulation of FTSJ3 has been linked to neurodevelopmental disorders, cancer, and viral infections, as proper rRNA processing is essential for protein synthesis and cell viability.
Antibodies targeting FTSJ3 enable researchers to investigate its expression, localization, and interactions in various tissues and disease models. These antibodies are typically validated for applications like Western blotting, immunofluorescence, or immunoprecipitation, aiding in elucidating FTSJ3’s role in RNA metabolism and disease mechanisms. Recent studies suggest FTSJ3 may influence pathways like p53 signaling and viral replication, highlighting its broader functional relevance. However, the protein’s exact substrates and regulatory networks remain under exploration, making FTSJ3 antibodies vital for advancing mechanistic insights into ribosome biology and associated pathologies.
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