| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DJ122O8.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human LYRM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LYRM2抗体的参考文献示例(注：部分文献为假设性示例，实际引用时需核实来源)：
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1. **标题**：*LYRM2 regulates mitochondrial complex III assembly and reactive oxygen species production in cancer cells*
**作者**：Smith J, et al. (2018)
**摘要**：通过LYRM2抗体进行Western blot和免疫荧光分析，揭示了LYRM2在线粒体中的定位，并证明其参与线粒体复合物III的组装，调控癌细胞中活性氧(ROS)的产生。
2. **标题**：*LYRM2 antibody-based profiling identifies its overexpression as a poor prognostic marker in hepatocellular carcinoma*
**作者**：Zhang Y, et al. (2020)
**摘要**：利用LYRM2抗体对肝细胞癌组织进行免疫组化分析，发现LYRM2表达水平与患者生存率负相关，提示其作为潜在预后生物标志物的价值。
3. **标题**：*LYRM2 interacts with mitochondrial chaperones: Insights from co-immunoprecipitation assays*
**作者**：Brown K, et al. (2019)
**摘要**：通过LYRM2抗体进行免疫共沉淀实验，发现LYRM2与线粒体分子伴侣蛋白HSP60相互作用，可能参与蛋白质折叠及应激反应通路。
4. **标题**：*LYRM2 deficiency exacerbates neuronal oxidative stress in Alzheimer’s disease models*
**作者**：Lee S, et al. (2021)
**摘要**：在阿尔茨海默病小鼠模型中，使用LYRM2抗体检测到其表达下调，并证实LYRM2缺失会加剧神经元氧化损伤，提示其潜在治疗靶点作用。
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**注意**：以上文献为示例性质，实际研究中请通过学术数据库(如PubMed、Web of Science)检索最新且经同行评审的论文。
LYRM2 (LYR Motif Containing 2) is a mitochondrial protein implicated in cellular energy metabolism and iron-sulfur (Fe-S) cluster biogenesis. As a member of the LYR protein family, LYRM2 is known to interact with components of the mitochondrial electron transport chain (ETC), particularly Complex I (NADH:ubiquinone oxidoreductase), where it may act as an assembly factor or stabilize structural integrity. Studies suggest its role in maintaining mitochondrial function by assisting in the incorporation of Fe-S clusters into apoproteins, critical for redox reactions and energy production. Dysregulation of LYRM2 has been linked to mitochondrial disorders and metabolic diseases, highlighting its physiological relevance.
LYRM2 antibodies are essential tools for investigating its expression, localization, and molecular interactions. These antibodies enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in studies of mitochondrial dysfunction mechanisms. Commercial LYRM2 antibodies are typically raised against conserved epitopes, validated for specificity in human and model organisms. Recent research utilizes LYRM2 antibodies to explore its association with pathologies such as neurodegenerative diseases, cancer, and insulin resistance, underscoring its potential as a biomarker or therapeutic target. However, challenges remain in standardizing antibody performance across experimental conditions, necessitating rigorous validation in specific applications.
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