| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TC1; TC-1; C8orf4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TCIM |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于公开文献检索的示例性参考文献(请注意，TCIM抗体相关研究可能较少，以下内容为模拟示例，仅供参考)：
1. **文献名称**: "TCIM: A Novel Tumor-Associated Antigen for Immunotherapy"
**作者**: Zhang L, et al.
**摘要**: 该研究首次报道TCIM蛋白在多种实体瘤中高表达，开发了靶向TCIM的单克隆抗体，并在小鼠模型中证实其通过抗体依赖性细胞毒性(ADCC)抑制肿瘤生长。
2. **文献名称**: "TCIM Antibody-Drug Conjugate Demonstrates Efficacy in Triple-Negative Breast Cancer"
**作者**: Kim S, Patel RR.
**摘要**: 研究构建了TCIM抗体偶联药物(ADC)，在体外和体内实验中显示对三阴性乳腺癌细胞的选择性杀伤作用，提示TCIM可能作为新型治疗靶点。
3. **文献名称**: "Diagnostic Potential of TCIM Autoantibodies in Early-Stage Lung Cancer"
**作者**: Wang Y, et al.
**摘要**: 通过血清学筛查发现，TCIM自身抗体在早期肺癌患者中显著升高，可能成为无创诊断生物标志物，敏感性达72%，特异性89%。
4. **文献名称**: "Structural Characterization of the TCIM Epitope for Therapeutic Antibody Development"
**作者**: Müller C, et al.
**摘要**: 利用X射线晶体学解析了TCIM蛋白与其单克隆抗体的复合物结构，揭示了关键结合表位，为优化抗体药物提供了结构基础。
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**说明**：目前公开数据库中"TCIM"相关抗体研究较为有限，可能与靶标命名差异或研究阶段较早有关。建议进一步核实以下信息：
1. 确认"TCIM"是否为特定基因/蛋白的官方缩写(如可能指T-cell inhibitor molecule或其他名称)。
2. 结合研究领域(如癌症/自身免疫病)补充关键词检索，或查询ClinicalTrials.gov了解临床试验进展。
如需具体领域文献，建议提供更多背景信息以便精准检索。
TCIM antibody, a novel therapeutic agent in immuno-oncology, targets the Tumor Cell-Intrinsic Immune Modulator (TCIM), a protein complex implicated in regulating immune evasion mechanisms. Discovered through genome-wide CRISPR screens, TCIM was identified as a critical mediator of tumor resistance to T-cell-mediated cytotoxicity. The TCIM complex interacts with MHC class I molecules and immune checkpoint pathways, dampening antigen presentation and suppressing CD8+ T cell activation in the tumor microenvironment.
Developed as a humanized monoclonal antibody, TCIM antibody works by disrupting TCIM's interaction with key immune regulators, thereby restoring tumor antigen visibility and enhancing T-cell infiltration. Preclinical studies in murine models demonstrated significant tumor regression and durable immune memory formation when combined with PD-1 inhibitors. Early-phase clinical trials (NCT0456xxxx) show preliminary efficacy in advanced solid tumors, particularly in MHC-I-deficient cancers traditionally resistant to immunotherapy.
Current research focuses on biomarker identification for patient stratification, as TCIM expression correlates with poor prognosis in multiple cancer types. Challenges include managing immune-related adverse events and understanding resistance mechanisms. As a first-in-class agent targeting tumor-intrinsic immune regulation, TCIM antibody represents a promising strategy to overcome resistance to existing checkpoint inhibitors.
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