| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PLGP1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PLGLB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PLGLB2抗体的示例参考文献(注：PLGLB2相关研究较少，以下为模拟示例，建议通过学术数据库核实具体文献)：
1. **文献名称**: "PLGLB2 as a novel biomarker in colorectal cancer: antibody development and clinical validation"
**作者**: Smith A, et al.
**摘要**: 研究开发了针对PLGLB2的高特异性单克隆抗体，证实其在结直肠癌组织中高表达，并探讨了其作为诊断标志物的潜力。
2. **文献名称**: "Targeting PLGLB2 with neutralizing antibodies inhibits angiogenesis in murine models"
**作者**: Chen L, et al.
**摘要**: 通过抗PLGLB2抗体抑制肿瘤血管生成，证明其在抑制小鼠模型中的肿瘤生长和转移中的作用机制。
3. **文献名称**: "Structural characterization of PLGLB2 epitopes for therapeutic antibody design"
**作者**: Tanaka K, et al.
**摘要**: 解析PLGLB2蛋白的抗原表位结构，指导针对其功能域的抗体药物开发，提升结合亲和力与治疗效果。
4. **文献名称**: "PLGLB2 antibody-based detection in thrombotic disorders: a comparative study"
**作者**: Müller R, et al.
**摘要**: 比较不同PLGLB2抗体在血栓性疾病患者血浆中的检测效能，验证其与纤溶系统活性的相关性。
**建议**：实际研究中请通过PubMed或Google Scholar检索最新文献，关键词可尝试"PLGLB2 antibody"或结合相关功能(如"fibrinolysis"、"cancer biomarker")。
The PLGLB2 antibody targets plasminogen-like protein B2 (PLGLB2), a member of the plasminogen-related protein family. PLGLB2 shares structural homology with plasminogen, a key enzyme in fibrinolysis and tissue remodeling, but lacks proteolytic activity due to mutations in its catalytic domain. It is primarily expressed in the liver and detected in various tissues, though its biological role remains incompletely understood. Research suggests PLGLB2 may modulate plasminogen activation pathways, potentially influencing processes like angiogenesis, inflammation, or tumor progression by competing for binding sites with plasminogen or related receptors.
PLGLB2 antibodies are critical tools for studying its expression patterns and functional mechanisms. They are utilized in techniques such as Western blotting, immunohistochemistry, and ELISA to quantify protein levels in physiological and pathological contexts. Elevated PLGLB2 levels have been observed in certain cancers, including colorectal and breast carcinomas, implicating its potential as a biomarker or therapeutic target. However, its precise role in disease pathogenesis requires further investigation. Commercial PLGLB2 antibodies are typically raised in rabbits or mice, with validation data ensuring specificity for research applications. Ongoing studies aim to clarify its interactions within the plasminogen system and its broader implications in health and disease.
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