| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SH3BGR; HEL-S-115 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SH3BGRL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SH3BGRL抗体的3篇示例参考文献(注：以下内容为假设性示例，实际文献需通过学术数据库验证)：
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1. **文献名称**：*SH3BGRL promotes tumor angiogenesis via enhancing VEGF signaling in hepatocellular carcinoma*
**作者**：Liu, Y. et al. (2019)
**摘要**：本研究利用SH3BGRL特异性抗体(兔多克隆)进行免疫组化和Western blot分析，发现SH3BGRL在肝癌组织中高表达，并通过增强VEGF信号通路促进肿瘤血管生成，提示其作为潜在治疗靶点。
2. **文献名称**：*SH3BGRL interacts with cardiac troponin I and modulates myocardial contractility*
**作者**：Xu, J. et al. (2017)
**摘要**：通过免疫共沉淀(Co-IP)和免疫荧光技术(使用小鼠单克隆SH3BGRL抗体)，作者揭示了SH3BGRL与心肌肌钙蛋白I的相互作用，并证实其参与调节心脏收缩功能，为心肌病机制研究提供新方向。
3. **文献名称**：*Diagnostic potential of SH3BGRL autoantibodies in rheumatoid arthritis*
**作者**：Kim, S. et al. (2021)
**摘要**：该研究使用ELISA和蛋白质芯片技术(基于人源SH3BGRL重组蛋白及对应抗体)，发现类风湿关节炎患者血清中SH3BGRL自身抗体水平显著升高，提示其可作为疾病诊断的生物标志物。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“SH3BGRL antibody”或“SH3BGRL + [研究领域]”，并筛选涉及抗体应用的实验研究(如Western blot、免疫组化等)。
SH3BGRL (SH3 domain-binding glutamic acid-rich protein-like) is a small, evolutionarily conserved protein encoded by the *SH3BGRL* gene. It belongs to the SH3BGR family, characterized by a central glutamic acid-rich region and a C-terminal SH3-binding motif. SH3BGRL interacts with SH3 domain-containing proteins, suggesting roles in signal transduction, protein-protein interactions, and cellular processes such as differentiation, apoptosis, and cytoskeletal organization. While its exact biological functions remain incompletely understood, SH3BGRL has been implicated in cancer, cardiovascular diseases, and metabolic disorders, with studies highlighting both tumor-suppressive and oncogenic potentials depending on context.
Antibodies targeting SH3BGRL are essential tools for investigating its expression, localization, and molecular mechanisms. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using SH3BGRL antibodies has revealed its differential expression in tissues such as heart, liver, and skeletal muscle, as well as altered levels in tumors compared to normal tissues. Some studies propose SH3BGRL as a biomarker for disease progression or therapeutic response. However, inconsistencies in reported roles (e.g., promoting or inhibiting cell migration) underscore the need for further validation of antibody specificity and functional studies. Current efforts focus on clarifying SH3BGRL’s interactions with signaling pathways like Ras/MAPK or PI3K/AKT, potentially unlocking therapeutic applications.
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