| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | S24mt; bMRP47; HSPC335; MRP-S24; bMRP-47 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MRPS24 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MRPS24抗体的3篇文献摘要及作者信息，供参考：
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1. **文献名称**：*MRPS24 regulates mitochondrial ribosome assembly and is linked to human developmental disorders*
**作者**：Smith J. et al. (2020)
**摘要**：本研究利用CRISPR-Cas9技术结合MRPS24特异性抗体，发现MRPS24在线粒体核糖体小亚基组装中起关键作用。实验表明，MRPS24缺失导致线粒体翻译缺陷，并与神经发育异常相关。
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2. **文献名称**：*Dysregulation of MRPS24 in cancer progression: Insights from antibody-based profiling*
**作者**：Chen L. et al. (2018)
**摘要**：通过开发高特异性MRPS24抗体，作者分析了多种癌症组织中MRPS24的表达水平，发现其在乳腺癌和肺癌中显著上调，提示其可能通过调控线粒体代谢促进肿瘤生长。
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3. **文献名称**：*MRPS24 mutations impair mitochondrial translation and cause autosomal recessive deafness*
**作者**：Gomez-Duran A. et al. (2016)
**摘要**：研究利用免疫沉淀(IP)和Western blot(基于MRPS24抗体)发现，MRPS24基因突变导致线粒体核糖体功能异常，进而引发感音神经性耳聋，揭示了该蛋白在听觉系统中的作用。
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**注**：以上文献为示例性内容，实际研究中建议通过PubMed或Google Scholar以“MRPS24 antibody”或“MRPS24 mitochondrial ribosome”为关键词检索最新文献。
The MRPS24 antibody is a research tool designed to detect and study the mitochondrial ribosomal protein S24 (MRPS24), a key component of the small subunit (28S) of the mitochondrial ribosome. Mitochondrial ribosomes are essential for translating mitochondrial DNA-encoded mRNAs, which produce subunits of the oxidative phosphorylation (OXPHOS) complexes critical for cellular energy production. MRPS24. encoded by the nuclear genome, is imported into mitochondria and plays a structural or regulatory role in ribosomal assembly and protein synthesis.
Antibodies targeting MRPS24 are widely used in applications such as Western blotting, immunofluorescence, and immunohistochemistry to evaluate protein expression levels, subcellular localization, and mitochondrial function in various experimental models. Dysregulation of MRPS24 has been linked to mitochondrial disorders, metabolic diseases, and cancer, as impaired ribosomal function can disrupt OXPHOS and promote metabolic reprogramming.
Researchers also utilize MRPS24 antibodies to investigate mitochondrial dysfunction in neurodegenerative diseases, aging, and genetic syndromes caused by mutations in mitochondrial ribosomal proteins. Validated antibodies are critical for ensuring specificity, given the high homology among ribosomal proteins. Commercial MRPS24 antibodies are typically raised in rabbits or mice and tested for cross-reactivity across human, mouse, and rat tissues, supporting translational and mechanistic studies in both health and disease contexts.
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