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Rabbit Polyclonal NXNL1 Antibody

  • 中文名： NXNL1抗体
  • 别    名： RDCVF; TXNL6
货号: IPDX09864
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesRDCVF; TXNL6
WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human NXNL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于NXNL1抗体的示例参考文献(注：因NXNL1研究较新且具体抗体文献有限，以下为模拟内容，建议通过PubMed或Google Scholar获取最新真实文献)：

1. **"NXNL1 Antibody Characterization in Retinal Degeneration Models"**

*作者：Smith A, et al.*

摘要：研究验证了NXNL1抗体的特异性，发现其在视网膜色素上皮细胞中高表达，并揭示NXNL1通过激活抗氧化通路延缓光感受器细胞凋亡。

2. **"NXNL1 as a Potential Biomarker in Diabetic Retinopathy"**

*作者：Zhang L, et al.*

摘要：通过ELISA和Western blot分析，发现糖尿病患者玻璃体中NXNL1蛋白水平显著降低，提示其抗体可能用于疾病诊断或治疗监测。

3. **"Structural Insights into NXNL1 Interaction with RdCVF Protein"**

*作者：Garcia-Reyes M, et al.*

摘要：利用免疫共沉淀(Co-IP)结合NXNL1抗体，揭示了NXNL1与RdCVF的分子互作机制，为视网膜神经保护提供新靶点。

注：以上文献为示例模板，实际文献请通过**PubMed**(https://pubmed.ncbi.nlm.nih.gov/)或**Google Scholar**以“NXNL1 antibody”或“Nucleoredoxin-like 1”为关键词检索。

背景信息

The NXNL1 antibody is a tool used to detect Nucleoredoxin-like 1 (NXNL1), a protein encoded by the NXNL1 gene. This protein belongs to the thioredoxin superfamily, characterized by redox-active cysteine residues, and plays roles in cellular redox regulation and antioxidant defense. NXNL1 is notably expressed in retinal cells, particularly rods and cones, and has been linked to retinal homeostasis and photoreceptor survival. Studies highlight its involvement in two splice variants: a truncated form (Rod-derived Cone Viability Factor, RdCVF) that promotes cone survival via metabolic support, and a full-length thioredoxin-like protein (RdCVFL) with antioxidative properties. Dysregulation of NXNL1 is associated with retinal degenerative diseases, such as retinitis pigmentosa, where photoreceptor apoptosis occurs. The NXNL1 antibody facilitates research into these mechanisms by enabling protein localization, expression analysis (e.g., via Western blot, immunohistochemistry), and functional studies in retinal degeneration models. Its applications extend to exploring NXNL1's potential roles beyond the retina, including neuronal protection and oxidative stress-related pathologies. Commercial NXNL1 antibodies are typically raised in rabbits or mice, with validation in specific experimental systems required to ensure specificity. Ongoing research aims to clarify its molecular interactions and therapeutic potential in neurodegenerative and ocular diseases.

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