Rabbit Polyclonal NXNL1 Antibody

The NXNL1 antibody is a tool used to detect Nucleoredoxin-like 1 (NXNL1), a protein encoded by the NXNL1 gene. This protein belongs to the thioredoxin superfamily, characterized by redox-active cysteine residues, and plays roles in cellular redox regulation and antioxidant defense. NXNL1 is notably expressed in retinal cells, particularly rods and cones, and has been linked to retinal homeostasis and photoreceptor survival. Studies highlight its involvement in two splice variants: a truncated form (Rod-derived Cone Viability Factor, RdCVF) that promotes cone survival via metabolic support, and a full-length thioredoxin-like protein (RdCVFL) with antioxidative properties. Dysregulation of NXNL1 is associated with retinal degenerative diseases, such as retinitis pigmentosa, where photoreceptor apoptosis occurs. The NXNL1 antibody facilitates research into these mechanisms by enabling protein localization, expression analysis (e.g., via Western blot, immunohistochemistry), and functional studies in retinal degeneration models. Its applications extend to exploring NXNL1's potential roles beyond the retina, including neuronal protection and oxidative stress-related pathologies. Commercial NXNL1 antibodies are typically raised in rabbits or mice, with validation in specific experimental systems required to ensure specificity. Ongoing research aims to clarify its molecular interactions and therapeutic potential in neurodegenerative and ocular diseases.