| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PC-TP; STARD2 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PCTP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PCTP(磷酸酯转移蛋白)抗体相关的代表性文献摘要，供参考：
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1. **文献名称**：*Phosphatidylcholine transfer protein (PCTP) promotes hepatocellular carcinoma progression through regulating the MEK/ERK pathway*
**作者**：Li X et al.
**摘要**：本研究利用PCTP特异性抗体进行免疫组化和Western blot分析，发现肝癌组织中PCTP显著高表达，并通过激活MEK/ERK信号通路促进肿瘤增殖和转移，提示PCTP可能作为肝癌治疗的潜在靶点。
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2. **文献名称**：*PCTP modulates amyloid-β metabolism by stabilizing BACE1 in Alzheimer's disease models*
**作者**：Wang Y et al.
**摘要**：通过免疫沉淀和免疫荧光技术结合PCTP抗体，研究揭示了PCTP通过结合并稳定β-分泌酶(BACE1)，促进淀粉样蛋白Aβ生成，在阿尔茨海默病模型中加剧神经病理损伤。
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3. **文献名称**：*Targeted deletion of phosphatidylcholine transfer protein alters lipid metabolism and insulin sensitivity in mice*
**作者**：van der Veen JN et al.
**摘要**：利用PCTP基因敲除小鼠模型和抗体检测，发现PCTP缺失导致肝脏脂质转运异常，引发胰岛素抵抗和脂肪肝表型，表明PCTP在脂代谢调控中起关键作用。
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4. **文献名称**：*Development of a high-affinity monoclonal antibody against PCTP for diagnostic applications*
**作者**：Sato R et al.
**摘要**：该研究报道了一种新型抗PCTP单克隆抗体的开发，验证了其在ELISA和免疫印迹中的高特异性，并成功应用于血清样本中PCTP水平的定量检测，为代谢综合征的临床诊断提供新工具。
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**注**：以上文献为示例性内容，实际引用需核对真实出版物。如需具体文献，建议通过PubMed或Web of Science以“PCTP antibody”或“phosphatidylcholine transfer protein”为关键词检索。
The phosphatidylcholine transfer protein (PCTP), encoded by the *PCTP* gene, facilitates intracellular transport of phosphatidylcholine (PC), a critical phospholipid in membrane structure and signaling. Primarily expressed in liver, brain, and steroidogenic tissues, PCTP regulates lipid metabolism by shuttling PC between organelles, influencing membrane fluidity, lipoprotein assembly, and lipid droplet dynamics. Its role extends to modulating cellular responses to oxidative stress and steroidogenesis.
PCTP-specific antibodies are vital tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research on PCTP's interaction partners and regulatory mechanisms. These antibodies also help explore PCTP's pathophysiological relevance, as dysregulation is linked to metabolic disorders (e.g., non-alcoholic fatty liver disease), atherosclerosis, and cancers where lipid reprogramming occurs.
Recent studies highlight PCTP's potential as a therapeutic target or biomarker. Antibodies are used to validate PCTP knockdown/knockout models and assess its role in lipid-related pathways. However, challenges remain in characterizing isoform-specific functions and tissue-dependent roles. Ongoing research leverages PCTP antibodies to dissect its cross-talk with lipid transporters (e.g., STARD proteins) and its impact on cellular lipid homeostasis, offering insights into metabolic and degenerative diseases.
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