| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EIF3CL; EIF3S8; eIF3-p110 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human EIF3C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于 **EIF3C抗体** 的虚构参考文献(示例格式，非真实文献)：
1. **文献名称**: *EIF3C overexpression in breast cancer: a potential therapeutic target*
**作者**: Smith A, et al.
**摘要**: 本研究利用EIF3C抗体检测乳腺癌组织中EIF3C蛋白表达水平，发现其高表达与肿瘤转移和患者生存率降低相关，提示EIF3C可能成为治疗靶点。
2. **文献名称**: *Development and validation of a monoclonal antibody against human EIF3C for translational research*
**作者**: Lee J, et al.
**摘要**: 文章报道了一种高特异性抗人EIF3C单克隆抗体的开发，并通过Western blot、免疫组化(IHC)验证其在细胞系和临床样本中的应用，证实其适用于蛋白质定位及定量分析。
3. **文献名称**: *EIF3C interacts with viral proteins to promote viral replication*
**作者**: Chen R, et al.
**摘要**: 通过免疫共沉淀(Co-IP)结合EIF3C抗体，研究发现EIF3C与特定病毒蛋白相互作用，促进病毒在宿主细胞内的复制，为抗病毒治疗提供新方向。
4. **文献名称**: *EIF3C regulates cell cycle progression via mTOR signaling pathway*
**作者**: Wang Y, et al.
**摘要**: 利用EIF3C抗体敲低实验，发现EIF3C通过mTOR通路调控细胞周期进程，其缺失导致G1期阻滞，揭示其在肿瘤细胞增殖中的关键作用。
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(注：以上文献及摘要均为示例性虚构内容，实际研究中请参考真实发表的学术论文。)
**Background of EIF3C Antibody**
Eukaryotic Initiation Factor 3 subunit C (EIF3C) is a critical component of the eukaryotic translation initiation factor 3 (EIF3) complex, which plays a central role in initiating protein synthesis by recruiting ribosomes to mRNA. The EIF3 complex, composed of 13 subunits (EIF3A-EIF3M), regulates the assembly of the 43S pre-initiation complex and ensures accurate start codon selection. EIF3C, encoded by the *EIF3C* gene, directly interacts with the 40S ribosomal subunit and other initiation factors, facilitating mRNA scanning and stabilizing translation machinery.
EIF3C antibodies are essential tools for studying translation regulation, cellular proliferation, and disease mechanisms. Dysregulation of EIF3C has been linked to cancers, viral infections, and developmental disorders, as its overexpression or mutations can disrupt translational fidelity, promoting oncogenesis or viral replication. Researchers use EIF3C-specific antibodies in techniques like Western blotting, immunoprecipitation, and immunofluorescence to quantify protein expression, map interactions, or localize EIF3C within cellular compartments.
These antibodies also aid in exploring post-translational modifications of EIF3C, such as phosphorylation, which may modulate its function in stress responses or cell cycle progression. However, challenges remain in ensuring antibody specificity due to structural similarities among EIF3 subunits. Validated EIF3C antibodies are crucial for elucidating its role in translational control and its potential as a therapeutic target in diseases characterized by aberrant protein synthesis.
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