| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human LTA4H |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PCSK5抗体的3篇示例参考文献(内容为示例，建议通过学术数据库查询真实文献)：
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1. **文献名称**: *PCSK5 regulates somatic cell reprogramming through TGF-β signaling*
**作者**: Li Y, et al.
**摘要**: 研究利用特异性PCSK5抗体进行免疫沉淀和Western blot分析，发现PCSK5通过调控TGF-β通路影响体细胞重编程，抗体被用于检测蛋白表达及细胞内定位。
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2. **文献名称**: *Proprotein convertase PCSK5 interacts with cancer-associated fibroblasts in tumor microenvironment*
**作者**: Smith J, et al.
**摘要**: 通过免疫组化(使用抗PCSK5单克隆抗体)和基因沉默实验，揭示了PCSK5在肿瘤相关成纤维细胞中的高表达及其对肿瘤侵袭的促进作用。
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3. **文献名称**: *Development of a neutralizing antibody against PCSK5 for metabolic disorder therapy*
**作者**: Chen L, et al.
**摘要**: 报道了一种新型中和性PCSK5抗体的开发，通过动物模型验证其可抑制肝脏脂质代谢异常，为代谢性疾病治疗提供了潜在策略。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“PCSK5 antibody”+具体研究领域(如癌症、代谢疾病等)，筛选近年高被引论文。
The PCSK5 antibody is a research tool targeting proprotein convertase subtilisin/kexin type 5 (PCSK5), a member of the proprotein convertase family responsible for proteolytic activation of precursor proteins. PCSK5. also known as PC5/6. plays critical roles in cleaving inactive proproteins into biologically active forms, including growth factors, hormones, and receptors. It exists in two isoforms (PC5A and PC5B) with distinct cellular localizations and functions, influencing processes like embryonic development, lipid metabolism, and viral entry (e.g., SARS-CoV-2). Dysregulation of PCSK5 is linked to cancers, cardiovascular diseases, and metabolic disorders, making it a potential therapeutic target.
PCSK5 antibodies are widely used to study its expression, localization, and molecular interactions. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Both monoclonal and polyclonal variants exist, with monoclonal antibodies offering higher specificity for specific isoforms or domains (e.g., catalytic or regulatory regions). Challenges include cross-reactivity with other convertases (e.g., PCSK3/Furin) due to structural similarities, necessitating rigorous validation. Recent studies focus on PCSK5's role in tumor progression and its interaction with extracellular matrix components, driving demand for reliable antibodies. Commercial availability from multiple biotech vendors supports diverse research applications, from basic biology to drug discovery.
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