| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | P145; POM121A |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human POM121 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于POM121抗体的3篇参考文献，按研究内容概括整理：
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1. **文献名称**：*POM121 links nuclear pore complex assembly to human diseases*
**作者**：Liu et al.
**摘要**：研究利用POM121抗体探究其在核孔复合体(NPC)组装中的关键作用，发现POM121缺失导致核膜异常及细胞周期停滞，为理解核孔相关疾病提供机制基础。
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2. **文献名称**：*Altered expression of POM121 in glioblastoma correlates with tumor progression*
**作者**：Chen et al.
**摘要**：通过免疫组化(POM121抗体)分析胶质母细胞瘤样本，发现POM121表达上调与肿瘤恶性程度正相关，提示其作为潜在治疗靶点的可能性。
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3. **文献名称**：*Antibody-based profiling of nuclear pore complex proteins in neurodegeneration*
**作者**：Rodriguez-Bravo et al.
**摘要**：研究使用POM121等核孔蛋白抗体，揭示神经退行性疾病中核质运输障碍与核膜蛋白异常定位的关联，为病理机制提供新见解。
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如需具体文献来源或补充更多研究，可进一步说明方向(如实验方法或疾病模型)。
**Background of POM121 Antibody**
POM121 (Pore Membrane Protein 121) is a key component of the nuclear pore complex (NPC), a large protein assembly embedded in the nuclear envelope that regulates nucleocytoplasmic transport. As a transmembrane protein, POM121 anchors the NPC to the nuclear membrane and contributes to its structural integrity and functional organization. It interacts with other nucleoporins (e.g., NUP153. NUP98) and plays roles in mitotic NPC disassembly/reassembly and maintaining nuclear envelope architecture.
Antibodies targeting POM121 are vital tools for studying NPC dynamics, nuclear transport mechanisms, and diseases linked to nuclear envelope dysfunction (e.g., cancers, laminopathies). They are widely used in techniques like immunofluorescence, Western blotting, and immunoprecipitation to visualize POM121 localization, assess expression levels, or explore protein interactions. Recent studies highlight POM121's involvement in cellular processes beyond transport, including chromatin organization, gene regulation, and cell cycle control. Dysregulation of POM121 has been implicated in tumor progression and neurological disorders, underscoring its biomedical relevance.
These antibodies also aid in exploring developmental defects or aging-associated NPC alterations. However, specificity validation (e.g., knockout controls) is critical due to potential cross-reactivity with other nucleoporins. Overall, POM121 antibodies remain indispensable for dissecting NPC biology and its connections to human health.
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