Rabbit Polyclonal PNRC2 Antibody

The PNRC2 (Proline-rich nuclear receptor coactivator 2) antibody is a tool used to detect and study the PNRC2 protein, a coactivator involved in nuclear receptor-mediated transcriptional regulation. PNRC2 interacts with nuclear receptors, such as estrogen receptor-alpha (ERα) and glucocorticoid receptor (GR), enhancing their transcriptional activity by bridging them to the basal transcription machinery. It contains proline-rich motifs that facilitate protein-protein interactions, particularly with components of the spliceosome and RNA-processing factors, suggesting roles beyond transcription, including mRNA splicing and stability. PNRC2 is ubiquitously expressed, localized predominantly in the nucleus, and implicated in metabolic regulation, cell proliferation, and apoptosis. Dysregulation of PNRC2 has been linked to cancers, obesity, and metabolic disorders. Researchers use PNRC2 antibodies in techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore its expression patterns, molecular interactions, and functional roles in disease models. These studies help clarify PNRC2's dual functions in transcriptional coactivation and RNA metabolism, highlighting its potential as a therapeutic target or biomarker. The antibody’s specificity and validation in detecting endogenous PNRC2 across species make it critical for mechanistic studies in nuclear receptor signaling and RNA biology.