| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RABL5 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human IFT22 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IFITM2抗体的参考文献示例(注：部分信息为虚构，仅供格式参考)：
1. **"IFITM2-mediated antiviral mechanisms in influenza A virus infection"**
*作者：Smith J, et al. (2015)*
摘要：本研究利用IFITM2特异性抗体进行免疫沉淀和共聚焦显微镜分析，证实IFITM2通过干扰病毒膜融合抑制甲型流感病毒入侵，抗体验证其在细胞内膜结构的定位。
2. **"Development and validation of a monoclonal antibody against human IFITM2 for diagnostic applications"**
*作者：Chen L, et al. (2018)*
摘要：报道一种高特异性抗人IFITM2单克隆抗体的开发，通过Western blot和流式细胞术验证其在乳腺癌组织中的表达上调，提示其作为肿瘤标志物的潜力。
3. **"IFITM2 restricts Zika virus replication by modulating autophagy"**
*作者：Wang Y, et al. (2020)*
摘要：使用IFITM2抗体进行敲低实验，发现IFITM2通过促进自噬体形成抑制寨卡病毒复制，抗体染色显示病毒感染后IFITM2在内体-溶酶体区室富集。
4. **"Comparative analysis of IFITM family protein expression using isoform-specific antibodies"**
*作者：Kumar R, et al. (2021)*
摘要：系统比较多种IFITM抗体(包括IFITM2)的特异性，揭示不同亚型在肺上皮细胞中的差异表达及对冠状病毒感染的协同抑制作用。
注：以上文献信息为模拟示例，实际引用时请查询PubMed等数据库获取真实文献。
The IFITM2 antibody is a research tool designed to detect interferon-induced transmembrane protein 2 (IFITM2), a member of the IFITM family. IFITM proteins are crucial components of the innate immune system, playing a key role in restricting viral infections, particularly against enveloped viruses like influenza, dengue, and SARS-CoV-2. IFITM2 is induced by type I and type II interferons and localizes to endosomal and lysosomal membranes, where it disrupts viral entry by altering membrane fluidity or trapping viral particles.
Antibodies targeting IFITM2 are widely used in virology and immunology research to study its expression, subcellular localization, and interaction with viral or host proteins. They are essential for techniques like Western blotting, immunofluorescence, and immunohistochemistry. IFITM2-specific antibodies also help investigate its role in disease contexts, such as cancer, where IFITM2 expression may correlate with tumor progression or immune evasion.
Recent studies highlight IFITM2's dual roles—while it restricts viral pathogens, its overexpression might contribute to inflammatory or autoimmune conditions. Researchers utilize these antibodies to explore tissue-specific expression patterns and regulatory mechanisms under different interferon-stimulated conditions. Validation of IFITM2 antibodies often includes knockout cell lines or siRNA-mediated silencing to ensure specificity, given the high homology among IFITM family members. These tools continue to advance our understanding of host-pathogen interactions and therapeutic targeting of antiviral pathways.
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